王述綺 副教授


Shu-Chi Wang, Associate Porfessor


  • 國立清華大學 生醫工程與環境科學系 博士
    Ph.D. Department of Biomedical Engineering and Environmental Sciences.
    National Tsing Hua University, Taiwan

經歷 (Experience)

  • 高雄醫學大學附設醫院 健康管理中心 助理研究員 2012-2018
    Research Scientist, Health Management Center,
    Kaohsiung Medical University Hospital.

  • 美國德州西南醫學中心 放射腫瘤中心 博士後研究員 2011-2012
    Postdoctoral Fellow, Department of Radiation Oncology.
    University of Texas Southwestern Medical Center, Dallas, USA.

  • 美國紐約醫學大學 醫學院 訪問學者(科技部千里馬計劃) 2007
    Visiting Graduate Students, Department of Pathology.
    New York University of Medicine, New York, USA.


研究主題 (Research Interest)


  • 病毒性肝細胞病變和相關肝癌之研究
     Study of viral-related cytopathic effect and hepatocellular carcinoma.

  • 腫瘤微環境的改變和療效的關係

    The correlation of tumor microenvironments alternation with treatment efficiency.

  • 細胞氧化壓力對DNA傷害和修復能力之探討

    Investigation of cellular oxidative DNA damage and repair ability.  


代表著作 (Publication)


1.         Yvonne Siphepho, Yi-Ting Lu, Ciniso Sylvester Shabangu, Jee-Fu Huang, Chung-Feng Huang, Ming-Lun Yeh, Ming-Lung Yu, Shu-Chi Wang. (2021, Oct). The Impact of Steatosis on Chronic Hepatitis C Progression & Response to Antiviral Treatments. Biomedicines., 17;9(10):1491. 本人為通訊作者.

2.         Ciniso Sylvester Shabangu, Phumelele Yvonne Siphepho, Chia-Yang Li, Wei-Chung Cheng, Ming-Ying Lu, Chung-Feng Huang, Ming-Lun Yeh, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Zu-Yau Lin, Ming-Lung Yu, Shu-Chi Wang. (2021, Sep).The Persistence of Hepatitis C Virus Infection in Hepatocytes Promotes Hepatocellular Carcinoma Progression by Pro-Inflammatory Interluekin-8 Expression. Biomedicines., 11;9(10):1446. MOST 108-2314-B-037-079-MY3.本人為通訊作者.

3.         Keva Joseph, Ciniso Sylvester Shabangu, Tyng-Yuan Jang, Chung-Feng Huang, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu, Shu-Chi Wang. (2021, Sep). The Prevalence and Serological Association of Hepatitis D Virus Genotypes in Taiwan. Pathogens, 10, 1227. MOST 108-2314-B-037-079-MY3. 本人為通訊作者.

4.         Po-Yen Lee, Yu-Hung Lai, Po-Len Liu, Ching-Chih Liu, Chia-Cheng Su, Fang-Yen Chiu, Wei-Chung Cheng, Shiuh-Liang Hsu, Kai-Chun Cheng, Li-Yi Chiu, Tzu-En Kao, Chia-Ching Lin, Yo-Chen Chang, Shu-Chi Wang, Chia-Yang Li. (2021, Sep). Toxicity of amantadine hydrochloride on cultured bovine cornea endothelial cells. Scientific reports. 16;11(1):18514.. 本人為通訊作者.

5.         Shu-Chi Wang, Chia-Yang Li, Wen-Tsan Chang, Wei-Chung Cheng , Chia-Hung Yen, Wen-Yu Tu, Zu-Yau Lin, Ching-Chih Lin, Ming-Lun Yeh, Chung-Feng Huang, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Yao-Li Chen, Ming-Lung Yu. (2021, May). Exosome-derived differentiation antagonizing non-protein coding RNA with risk of HCV-related hepatocellular carcinoma recurrence. Liver International, 41(5):956-968. MOST 108-2314-B-037-079-MY3. 本人為第一作者.

6.         I-Chen Chen, Shu-Chi Wang, Yi-Ting Chen, Hsin-Han Tseng, Po-Len Liu, Tzu-Chieh Lin, Hsin-En Wu, Yuan-Ru Chen, Yu-Hsin Tseng, Jong-Hau Hsu, Zen-Kong Dai, Jau-Ling Suen, Chia-Yang Li. (2021, Oct). Corylin Ameliorates LPS-Induced Acute Lung Injury via Suppressing the MAPKs and IL-6/STAT3 Signaling Pathways. Pharmaceuticals (Basel). 14;14(10):1046.

7.         Po-Yen Lee, Ching-Chih Liu, Shu-Chi Wang, Kai-Yin Chen, Tzu-Chieh Lin, Po-Len Liu, Chien-Chih Chiu, I-Chen Chen, Yu-Hung Lai, Wei-Chung Cheng, Wei-Ju Chung, Hsin-Chih Yeh, Chi-Han Huang, Chia-Cheng Su, Shu-Pin Huang, Chia-Yang Li. (2021, Aug). Mycotoxin Zearalenone Attenuates Innate Immune Responses and Suppresses NLRP3 Inflammasome Activation in LPS-Activated Macrophages. Toxins, 25;13(9):593.

8.         Ming-Lun Yeh, Po-Cheng Liang, Pei-Chien Tsai, Shu-Chi Wang, Jennifer Leong, Eiichi Ogawa, Dae Won Jun, Cheng-Hao Tseng, Charles Landis, Yasuhito Tanaka, Chung-Feng Huang, Jun Hayashi, Yao-Chun Hsu, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Mindie H Nguyen, Ming-Lung Yu. (2021, Jul). Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR. Cancers (Basel). 2021 Jul 9;13(14):3455.

9.         Tsung-Ying Yang, Hao-Yun Kao, Po-Liang Lu, Pei-Yu Chen, Shu-Chi Wang, Liang-Chun Wang, Ya-Ju Hsieh, Sung-Pin Tseng. (2021, Aug). Evaluation of the Organotellurium Compound AS101 for Treating Colistin- and Carbapenem-Resistant Klebsiella pneumoniae. Pharmaceuticals., 12;14(8):795..

10.      Jeffrey Yung-Chuan Chao, Hsin-Chuan Chang, Jeng-Kai Jiang, Chih-Yung Yang, Fang-Hsin Chen, Yo-Liang Lai, Wen-Jen Lin, Chia-Yang Li, Shu-Chi Wang, Muh-Hwa Yang, Yu-Feng Lin, Wei-Chung Cheng. (2021, Jul). Using bioinformatics approaches to investigate driver genes and identify BCL7A as a prognostic gene in colorectal cancer. Computational and structural biotechnology journal., 1;19:3922-3929..

11.      Chi-Han Huang, Shu-Chi Wang, I-Chen Chen, Yi-Ting Chen, Po-Len Liu, Shih-Hua Fang, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Po-Yen Lee, Tzu-Chieh Lin, Wei-Chung Cheng, Chia-Cheng Su, Hsin-En Wu, Yuan-Ru Chen, Chia-Yang Li. (2021, Jun). Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation. Pharmaceuticals., 18;14(6):588..

12.      Chia-Cheng Su, Shu-Chi Wang, I-Chen Chen, Fang-Yen Chiu, Po-Len Liu, Chi-Han Huang, Kuan-Hua Huang, Shih-Hua Fang, Wei-Chung Cheng, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Po-Yen Lee, Ming-Yii Huang, Chia-Yang Li. (2021, May). Zerumbone Suppresses the LPS-Induced Inflammatory Response and Represses Activation of the NLRP3 Inflammasome in Macrophages. Frontiers in pharmacology., 11;12:652860..

13.      Shu-Hsuan Liu, Kai-Wen Hsu, Yo-Liang Lai, Yu-Feng Lin, Fang-Hsin Chen, Pei-Hwa Peng, Li-Jie Lin, Heng-Hsiung Wu, Chia-Yang Li, Shu-Chi Wang, Min-Zu Wu, Yuh-Pyng Sher, Wei-Chung Cheng, (2021, May). Systematic identification of clinically relevant miRNAs for potential miRNA-based therapy in lung adenocarcinoma. Molecular therapy. Nucleic acids., 1;25:1-10..

14.      Lu MY, Chen CT, Shih YL, Tsai PC, Hsieh MH, Huang CF, Yeh ML, Huang CI, Wang SC, Tsai YS, Ko YM, Lin CC, Chen KY, Wei YJ, Hsu PY, Hsu CT, Jang TY, Liu TW, Liang PC, Hsieh MY, Lin ZY, Chen SC, Huang JF, Dai CY, Chuang WL, Yu ML, Chang WY. (2021, Apr). Changing epidemiology and viral interplay of hepatitis B, C and D among injecting drug user-dominant prisoners in Taiwan. Scientific reports, 20;11(1):8554..

15.      Tyng-Yuan Jang, Yu-Ju Wei, Ming-Lun Yeh, Shu-Fen Liu, Cheng-Ting Hsu, Po-Yao Hsu, Ta-Wei Liu, Yi-Hung Lin, Po-Cheng Liang, Meng-Hsuan Hsieh, Yu-Min Ko, Yi-Shan Tsai, Kuan-Yu Chen, Ching-Chih Lin, Pei-Chien Tsai, Shu-Chi Wang, Ching-I Huang, Zu-Yau Lin, Shinn-Cherng Chen, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Chung-Feng Huang, Ming-Lung Yu. (2021, Apr). Role of hepatitis D virus in persistent alanine aminotransferase abnormality among chronic hepatitis B patients treated with nucleotide/nucleoside analogues. Journal of the Formosan Medical Association. 120(1 Pt 2):303-310.

16.      Liu WL, Li CY, Cheng WC, Chang CY, Chen YH, Lu CY, Wang SC, Liu YR, Cheng MH, Chong IW, Liu PL. (2021, Mar). High Mobility Group Box 1 Promotes Lung Cancer Cell Migration and Motility via Regulation of Dynamin-Related Protein 1. International Journal of Molecular Sciences, 31;22(7):3628..

17.      Ting-Yi Lin, Meng-Chun Tsai, Wei Tu, Hsin-Chih Yeh, Shu-Chi Wang, Shu-Pin Huang, Chia-Yang Li (2021, Feb). Role of the NLRP3 Inflammasome: Insights Into Cancer Hallmarks.. Front Immunol., 3;11:610492..

18.      Yu-Hung Lai, Po-Yen Lee, Chi-Yu Lu, Yu-Ru Liu, Shu-Chi Wang, Ching-Chih Liu, Yo-Chen Chang, Yung-Hsiang Chen, Chia-Cheng Su, Chia-Yang Li, Po-Len Liu. (2021, Jan). Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing. FASEB J.


19.      Tyng-Yuan Jang, Yu-Ju Wei, Cheng-Ting Hsu, Po-Yao Hsu, Ta-Wei Liu, Yi-Hung Lin, Po-Cheng Liang, Meng-Hsuan Hsieh, Yu-Min Ko, Yi-Shan Tsai, Kuan-Yu Chen, Ching-Chih Lin, Pei-Chien Tsai, Shu-Chi Wang, Ching-I Huang, Ming-Lun Yeh, Zu-Yau Lin, Shinn-Cherng Chen, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Chung-Feng Huang, Ming-Lung Yu. (2020, Nov). Serial serologic changes of hepatitis D virus in chronic hepatitis B patients receiving nucleos(t)ides analogues therapy. Journal of gastroenterology and hepatology..

20.      Ciniso Sylvester Shabangu, Jee-Fu Huang, Hui-Hua Hsiao, Ming-Lung Yu, Wan-Long Chuang, Shu-Chi Wang (2020, May). Liquid Biopsy for the Diagnosis of Viral Hepatitis, Fatty Liver Steatosis, and Alcoholic Liver Diseases. International Journal of Molecular Sciences, 21:1-3732. MOST 108-2314-B-037-079-MY3. 本人為通訊作者.

21.      Shu-Hsuan Liu, Pei-Chun Shen, Chen-Yang Chen, An-Ni Hsu, Yi-Chun Cho, Yo-Liang Lai, Fang-Hsin Chen, Chia-Yang Li, Shu-Chi Wang, Ming Chen, I-Fang Chung, Wei-Chung Cheng. (2020, Jan). DriverDBv3: a multi-omics database for cancer driver gene research. Nucleic acids research.


22.      Yung-Li Hung., Shu-Chi Wang., Katsuhiko Suzukic., Shih-Hua Fang., Chi-Shuo Chen., Wei-Chun gCheng., Chia-Cheng Su., Hsin-Chih Yeh.,Hung-Pin Tu. Po-Len Li., Ming-Yii Huang., Chia-Yang Li. (2019, Jun). Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages.. Phytomedicine., 59:152785..

23.      Chia-Chi Liu, Ching-Fang Yu, Shu-Chi Wang, Hsueh-Yin Li, Chiu-Min Lin, Hsia-Han Wang, Carmen Abate, Chi-Shiun Chiang (2019, May). Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor. BMC Cancer, 20;19(1):473-482.

24.      Hsuan-Fu Kuo, Chong-Chao Hsieh, Shu-Chi Wang, Chia-Yuan Chang, Chih-Hsin Hung, Po-Lin Kuo, Yu-Ru Liu, Chia-Yang Li, Po-Len Liu. Simvastatin Attenuates Cardiac Fibrosis via Regulation of Cardiomyocyte-Derived Exosome Secretion. J Clin Med. 2019 Jun 4;8(6):794.

25.      Chung-Feng Huang, Shu-Chi Wang, Ming-Lun Yeh, Ching-I Huang, Pei-Chien Tsai, Zu-Yau Lin, Shinn-Cherng Chen, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Angela Chen, Ming-Lung Yu. (2019, Jan). Association of serial serum major histocompatibility complex class I chain-related A measurements with hepatocellular carcinoma in chronic hepatitis C patients after viral eradication. . Journal of Gastroenterology and Hepatology., 34(1):249-255.


26.      Yung-Li Hung, Shu-Chi Wang, Katsuhiko Suzuki, Shih-Hua Fang, Chi-Shuo Chen, Wei-Chung Cheng, Chia-Cheng Su, Hsin-Chih Yeh, Hung-Pin Tu, Po-Len Liu, Ming-Yii Huang, Chia-Yang Li. (2018, Dec). Bavachin attenuates LPS-induced inßammatory response and inhibits the activation of NLRP3 inßammasome in macrophages. Phytomedicine.

27.      Ming-Yii Huang, Chia-En Tu, Shu-Chi Wang, Yung-Li Hung, Chia-Cheng Su, Shih-Hua Fang, Chi-Shuo Chen, Po-Len Liu, Wei-Chung Cheng, Yu-Wei Huang, Chia-Yang Li. (2018, Aug). Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia.. BMC Complementary and Alternative Medicine.

28.      Kuo-Hua Lin, Ming-Yii Huang, Wei-Chung Cheng, Shu-Chi Wang, Shih-Hua Fang, Hung-Pin Tu, Chia-Cheng Su, Yung-Li Hung, Po-Len Liu, Chi-Shuo Chen, Yu-Ting Wang, Chia-Yang Li. (2018, Feb). RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment.. Scientific Reports., 8(1):2672..


29.      Chia-Yen Dai, Yi-Shan Tsai, Wen-Wen Chou, Tawei Liu, Chung-Feng Huang, Shu-Chi Wang, Pei-Chien Tsai, Ming-Lun Yeh, Ming-Yen Hsieh, Ching-I Huang, Shang-Yin Vanson Liu, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu (2018, Jan). The IL-6/STAT3 pathway upregulates microRNA-125b expression in hepatitis C virus infection. Oncotarget

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