吳世忠 副教授

·       台灣大學生理學研究所博士

·       高雄醫學院醫學技術學系學士

·       高雄醫學大學醫學檢驗生物技術學系 副教授 (2015~)

·       加拿大蒙特婁大學博士後研究 (2006-2008)

·       高雄醫學大學醫學檢驗生物技術學系助理教授 (2004-2015)

·       中央研究院動物所博士後研究 (2004)

基因多型性(SNP)在慢性疾病(高血壓、中的功能與角色。

神經退化疾病(失智症)的致病機轉與預防機制。

糖尿病腎病變致病基因與致病機制的研究。

心血管疾病中粥狀動派硬化致病基因的探討與致病機轉的研究。

·       2017高雄醫學大學績優書院導師

·       2016 KMU Outstanding Faculty Research Award (研究績優教師/優秀論文獎)

·       2013 KMU Outstanding Faculty Research Award (IF>5) (研究績優教師/優秀論文獎)

Publications論文著作 (*corresponding author)

1.             Hsing-Mei Chen , Shan-Tair Wang , Shyh-Jong Wu , Chee-Siong Lee , Susan J Fetzer , Liang-Miin Tsai (2020 Oct). Effects of Predischarge Patient Education Combined With Postdischarge Follow-Ups on Self-Care, Readmission, Sleep, and Depression in Patients With Heart Failure. Journal of Nursing Research. 2020 Oct;28(5):e112

2.             Yi-Ting Lin, Mei-Chuan Chou, Shyh-Jong Wu, Yuan-Han Yang (2019 May). Galantamine plasma concentration and cognitive response in Alzheimer's disease. PeerJ. 2019 May 2;7:e6887. doi: 10.7717/peerj.6887.

3.             Ming-Chi Lai, Te-Yu Hung, Kao-Min Lin, Pi-Shan Sung, Shyh-Jong Wu, Chih-Sheng Yang, Yi-Jen Wu, Jing-Jane Tsai, Sheng-Nan Wu, Chin-Wei Huang* (2018, Jul). Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity.. Neurotoxicity Research, 34(1):1-15. doi: 10.1007/s12640-017-9844-4. Epub 2017 Nov 29.PMID: 29188487.

4.             Ping-Song Chou, Shyh-Jong Wu, Yi-Hui Kao, Mei-Chuan Chou, Shu-Yu Tai, Yuan-Han Yang* (2017, Jun). Angiotensin-converting enzyme insertion/deletion polymorphism is associated with cerebral white matter changes in Alzheimer's disease.. Geriatrics & Gerontology International, 17(6):945-950.

5.             Tzu-Hua Chen, Mei-Chuan Chou, Chiou-Lian Lai, Shyh-Jong Wu, Chia-Ling Hsu, Yuan-Han Yang* (2017, Jun). Factors affecting therapeutic response to Rivastigmine in Alzheimer's disease patients in Taiwan.. Kaohsiung Journal of Medical Sciences, 33(6):277-283.

6.             Yuan-Han Yang, Hsueh-Wei Chang, Wei-Chiao Chang, Yu-Cheng Shih, Ke-Li Tsai, I Chien and Shyh-Jong Wu* (2016, Aug). Pharmarcogenetic Mechanism of ACE I/D Polymorphism Adversely Responding to ACE Inhibitors in Regulating the ACE Promoter Activity in Neurons. Journal of Pharmacy and Pharmacology, pp.419-431. 

7.             Poh-Shiow Yeh#, Shyh-Jong Wu#, Te-Yu Hung, Yan-Ming Huang, Chia-Wei Hsu, Chun-I Sze, Chin-Wei Huang*, Sheng-Nan Wu* (2016, May). Evidence for the Inhibition by Temozolomide, an Imidazotetrazine Family Alkylator, of Intermediate-Conductance Ca2+-Activated K+ Channels in Glioma Cells. Cellular physiology and biochemistry, 38(5):1727-42.( #共同第一作者. )

8.             Shyh-Jong Wu, Yu-Shin Cheng, Hsiao-Lung Liu, Hsing-He Wang, Hsiu-Lin Huang*. (2016, May). Global transcriptional expression in ovarian follicles from Tsaiya ducks (Anas platyrhynchos) with a high-fertilization rate.. THERIOGENOLOGY, May;85(8):1439-1445. 

9.             Ya-Ju Hsieh, Luen Hwu, Chien-Chih Ke, Ai-Lin Huang, Fu-Du Chen, Shyh-Jong Wu, Sharon Chia-Ju Chen, Yong-Hua Zhao, Ren-Shyan Liu (2015, Dec). Demonstration of Tightly Radiation-Controlled Molecular Switch Based on CArG Repeats by In Vivo Molecular Imaging.. Molecular Imaging and Biology, 17(6):802-10.

10.         Ya-Ying Wu, Jung-Lung Hsu, Han-Cheng Wang, Shyh-Jong Wu, Chen-Jee Hong, Irene Han-Juo Cheng (2015, Nov). Alterations of the Neuroinflammatory Markers IL-6 and TRAIL in Alzheimer's Disease.. Dementia and Geriatric Cognitive Disorders Extra, 5(3):424-34.

11.         Ammad Ahmad Farooqi, Shyh-Jong Wu, Yung-Ting Chang, Jen-Yang Tang, Kun-Tzu Li, Muhammad Ismail, Chih-Chuang Liaw, Ruei-Nian Li , Hsueh-Wei Chang (2015, Oct). Activation and Inhibition of ATM by Phytochemicals: Awakening and Sleeping the Guardian Angel Naturally.. Archivum Immunologiae et Therapiae Experimentalis, 63(5):357-66.

12.         Shyh-Jong Wu, Mathilde Soulez , Ya-Hui Yang , Chih-Sheng Chu, Shih-Chuan Shih, Marie-Josée Hébert, Mei-Chuan Kuo, Ya-Ju Hsieh (2015, Jul). Local Augmented Angiotensinogen Secreted from Apoptotic Vascular Endothelial Cells Is a Vital Mediator of Vascular Remodelling. PLoS One, 10(7):e0132583. 第一作者.

13.         Cheng-Hong Yang, Yu-Da Lin, Shyh-Jong Wu*, Li-Yeh Chuang*, and Hsueh-Wei Chang* (2015, Apr). High order gene-gene interactions in eight single nucleotide polymorphisms of renin-angiotensin system genes for hypertension association study.. BioMed Research International, 2015;2015:454091.. 通訊作者.

14.         Shyh-Jong Wu, Yun-Ju Chen, Tien-Yu Shieh, Chun-Ming Chen, Yen-Yun Wang, Kun-Tsung Lee, Yueh-Ming Lin, Pei-Hsuan Chien, and Ping-Ho Chen* (2015, Mar). Association study between novel CYP26 polymorphisms and the risk of betel quid-related malignant oral disorders. Scientific World Journal , 2015:160185. 第一作者.

15.         Chia-Che Wu∗, Bien-Chen Ku, Chien-Hsien Ko, Chun-Che Chiu, Gou-Jen Wang, Yuan-Han Yang, Shyh-Jong Wu (2014, May). Electrochemical impedance spectroscopy analysis of A-beta (1-42) peptide using a nanostructured biochip. Electrochimica Acta, 134: 249–257.

16.         Jing-Ru Liou, Li-Yeh Chuang, Yuan-Han Yang, Tung-Ying Wu, Mohamed El-Shazly, Shyh-Jong Wu, Tusty-Jiuan Hsieh, Yang-Chang Wu, Jiumn-Yih Wu, Fang-Rong Chang* (2014, Feb). Fast quantification of S-adenosyl-L-methionine in dietary health products utilizing reversed-phase high-performance liquid chromatography: teaching an old method new tricks. Planta Med, 80(2-3):243-8.

17.         Yuan-Han Yang, Tusty-Jiuan Hsieh, Mei-Lan Tsai, Chun-Hung Chen, Hsin-Ting Lin, Shyh Jong Wu* (2014, Feb). Neuroprotective effects of Hu-Yi-Neng, a diet supplement, oin SH-SY5Y human neuroblastoma cells. J Nutr Health Aging, 18(2):184-90. (通訊作者).

18.         Ya-Hui Yang#; Shyh Jong Wu#; Saou Hsing Liou; Chao Ling Wang; Chun Yuh Yang; Trong-Neng Wu*. (2013, Oct). Incidence of needlestick and other sharp object injuries in newly graduated nurses.. American Journal of Infection Control, 41(10):944-5. (第一作者.)

19.         Shyh-Jong Wu, Li-Yeh Chuang, Yu-Da Lin, Wen-Hsien Ho, Fu-Tien Chiang, Cheng-Hong Yang, Hsueh-Wei Chang* (2013, Jul). Particle swarm optimization algorithm for analyzing SNP–SNP interaction of renin-angiotensin system genes against hypertension. Molecular Biology Reports, 40(7), 4227-33..

20.         Shyh-Jong Wu, Tusty-Jiuan Hsieh, Mei-Chuan Kuo, Mei-Lan Tsai, Ke-Li Tsai, Chun-Hung Chen, Yuan-Han Yang*. (2013, Jul). Functional regulation of Alu element of human angiotensin-converting enzyme gene in neuron cells. Neurobiology of Aging, 34(7):1921.e1-7.

21.         Wei-Pin Chang, Shyh-Jong Wu, Wei-Chiao Chang, Ho-Chang Kuo (2013, Jun). Population-based study of the association between urbanization and Kawasaki disease in Taiwan. Scientific World Journal, 2013:169365.

22.         Hsing-Mei Chen, Angela P Clark, Liang-Miin Tsai, Yi Liu, Li-Min Wu, Shyh-Jong Wu* (2013, Mar). Excessive Daytime Sleepiness in Taiwanese People with Heart Failure. J Nurs Res, 21(1):39-48.

23.         Ching-Wen Huang, Shang-Jang Wang, Shyh-Jong Wu, Ching-Chung Yang, Ming-Wei Huang, Chieh-Hsin Lin, Irene H Cheng* (2013, Feb). Potential blood Biomarker for Disease Severity in the Taiwanese Population with Alzheimer’s Disease. American Journal of Alzheimer's Disease and Other Dementias, 28(1):75-83.. doi: 10.1177/1533317512467674

24.         Ming-Hui Yang, Yuan-Han Yang, Chi-Yu Lu, Shiang-Bin Jong, Li-Jhen Chen, Yu-Fen Lin, Shyh-Jong Wu, Pei-Yu Chu, Tze-Wen Chung, Yu-Chang Tyan (2012 Jun). Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease. J Proteomics. 75(12):3617-29. doi: 10.1016.

25.         Mathilde Soulez, Eve-Annie Pilon, Mélanie Dieudé, Héloïse Cardinal, Nathalie Brassard, Shijie Qi, Shyh-Jong Wu, Yves Durocher, François Madore, Claude Perreault, Marie-Josée Hébert* (2012 Jan). The Perlecan Fragment LG3 Is a Novel Regulator of Obliterative Remodeling Associated With Allograft Vascular Rejection. Circ Res. 6;110(1):94-104. (SCI)

26.         Garnet J Lau, Nicolas Godin, Hasna Maachi, Chao-Sheng Lo, Shyh-Jong Wu, Jian-Xin Zhu, Marie-Luise Brezniceanu, Isabelle Chénier, Joelle Fragasso-Marquis, Jean-Baptiste Lattouf, Jean Ethier, Janos G Filep, Julie R Ingelfinger, Viji Nair, Matthias Kretzler, Clemens D Cohen, Shao-Ling Zhang, John S D Chan* (2012 Feb). Bcl-2 modifying factor induces renal proximal tubular cell apoptosis in diabetic mice. Diabetes.;61(2):474-84. (SCI)

27.         James Cheng-Chung Wei, Kuo-Sheng Hung, Yu-Wen Hsu, Ruey-Hong Wong, Chun-Huang Huang, Ming-Shiou Jan, Shyh-Jong Wu, Yung-Shun Juan, Wei-Chiao Chang (Epub 2012 Dec) Genetic polymorphisms of stromal interaction molecule 1 associated with the erythrocyte sedimentation rate and C-reactive protein in HLA-B27 positive ankylosing spondylitis patients. PLoS One 7(12):e49698. doi: 10.1371

28.         Mei-Chuan Chou, Chun-Hung Chen, Ching-Kuan Liu, Su-Hwei Chen, Shyh-Jong Wu, Yuan-Han Yang* (2012). Concentrations of rivastigmine and NAP 226-90 and the cognitive response in Taiwanese Alzheimer's disease patients. J Alzheimers Dis. 31(4):857-64. doi: 10.3233.

29.         Fang Liu, Chih-Chang Wei, Shyh-Jong Wu, Isabelle Chenier, Shao-Ling Zhang, Janos G Filep, Julie R Ingelfinger, John S D Chan* (2009 Jan). Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension. Kidney Int.;75(2):156-66. (SCI)

30.         Shyh-Jong Wu, Fu-Tien Chiang, Wei J Chen, Pi-Hua Liu, Kwan-Lih Hsu, Juey-Jen Hwang, Ling-Ping Lai, Jiunn-Lee Lin, Chuen-Den Tseng, Yung-Zu Tseng*. Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: single locus genotype vs. haplotype analysis. Physiol Genomics. 2004,17(2):79-86. (SCI)

31.         Shyh-Jong Wu, Fu-Tien Chiang, Jun-Ran Jiang, Kwan-Lih Hsu, Tser-Haw Chern, Yung-Zu Tseng* (2003 Nov). The G–217A variant of the angiotensinogen gene affects basal transcription and is associated with hypertension in a Taiwanese population. J Hypertens.;21(11):2061-2067. (SCI)

32.         Chen WH, Chu KC, Wu SJ, Wu JC, Shui HA, Wu ML* (1999 Feb). Early metabolic inhibition-induced intracellular sodium and calcium increase in rat cerebellar granule cells. J. Physiol. (Lond.) 15;515 ( Pt 1):133-46. (SCI)

1.      “Molecular variants of angiotensinogen gene promoter affect in-vitro basal transcription” Wu SJ, Chiang FT, Jiang JR, Hsu KL, Chern TH, Tseng YZ. The 24th Annual Scientific Meeting of Japanese Society of Hypertension 2001. (Held at OSAKA, ). (Oral presentation of young investigators)

2.      “BCL-2 MODIFYING FACTOR IS DIFFERENTIALLY UPREGULATED AND INDUCES APOPTOSIS IN RENAL PROXIMAL TUBULAR CELLS OF DB/DB MICE” Wu SJ, Liu F, Wei CC, Chenier I, Zhang SL, Filep JG, Ingelfinger JR, Chan JS*. The Canadian Society of Nephrology Annual Meeting at the London Convention Centre, London, Ontario , May 30th to June 1st, 2008. (Oral presentation)

3.      “The initiatory source of local Ang II to induce vascular remodeling comes from the apoptotic endothelial cells” Wu SJ*, Tsai ML, Chiang FT, Hébert MJ 21st European Meeting on Hypertension and Cardiovascular Prevention at Milano, Italy, Jun 17th-20th, 2011 (Poster)

4.      “Functional Regulation of Alu Element of ACE Gene in Neuron Cell” Wu SJ, Tsai ML, Chen CH, Yang YH*. The Fifth Congress of the Asian Society Against Dementia at Hongkong, Nov 5th-7th, 2011. (Oral presentation)

5.      “Functional examination of HU-YI-NENG, diet supplement, in its anti-oxidant effects” Wu SJ*, Chen CH, Tsei ML, Hseih TJ, Yang YH. Alzheimer’s Association International Conference (AAIC), Vancouver, British Columbia, Canada, Jul 14th-19th, 2012. (Poster)

1.      『祥和護憶能膠囊對神經細胞保護的效用評估』，執行期間100.05.15~100.9.31；

2.      『祥和星月寧膠囊對神經細胞血清素分泌的調節作用』，執行期間101.02.01~101.9.31。