褚佩瑜 教授

學歷

• 高雄醫學大學醫學研究所博士
• 高雄醫學大學醫學研究所碩士

經歷

• 高雄醫學大學醫學檢驗生物技術學系副教授
• 高雄醫學大學醫學檢驗生物技術學系助理教授
• 高雄醫學大學醫學檢驗生物技術學系講師

研究興趣

病毒的分子流行病學、再組合抗體在診斷及治療製劑之研發

研究計畫

論文著作 (*corresponding author) (近期)

期刊論文

1. Hung CC, Chien CY, Chu PY, Wu YJ, Lin CS, Huang CJ, Chan LP, Wang YY, Yuan SF, Hour TC, Chen JY. Differential resistance to platinum-based drugs and 5-fluorouracil in p22phox-overexpressing oral squamous cell carcinoma: Implications of alternative treatment strategies. Head Neck. 2017 Aug;39(8):1621-1630. doi: 10.1002/hed.24803. Epub 2017 May 12. PMID: 28498554 (SCI)
2. Boonchan M, Motomura K, Inoue K, Ode H, Chu PY, Lin M, Iwatani Y, Ruchusatsawat K, Guntapong R, Tacharoenmuang R, Chantaroj S, Tatsumi M, Takeda N, Sangkitporn S. Distribution of norovirus genotypes and subtypes in river water by ultra-deep sequencing-based analysis. Lett Appl Microbiol. 2017 Jul;65(1):98-104. doi: 10.1111/lam.12750. PMID: 28434202 (SCI) 國際合作
3. Yen YC, Chu PH, Lu PL, Lin YC, Shi YY, Chou LC, Wang CF, Lin YY, Su HJ, Lin CC, Zeng JY, Tyan YC, Ke GM, Chu PY*. Phylodynamic Characterization of an Ocular-Tropism Coxsackievirus A24 Variant. PLoS One. 2016 Aug 16;11(8):e0160672. doi: 10.1371/journal.pone.0160672. eCollection 2016. PMID: 27529556
4. Mori K, Chu PY, Motomura K, Somura Y, Nagano M, Kimoto K, Akiba T, Kai A, Sadamasu K. Genomic analysis of the evolutionary lineage of Norovirus GII.4 from archival specimens during 1975-1987 in Tokyo. J Med Virol. 2017 Feb;89(2):363-367. doi: 10.1002/jmv.24624. Epub 2016 Jul 13. PMID: 27380721 (SCI) 國際合作
5. Saeng-Aroon S, Loket R, Plipat T, Lumyai S, Chu PY, Sangkitporn S, Nakayama EE, Takeda N, Shioda T, Motomura K*. Circulation of HIV-1 Multiple Complexity Recombinant Forms Among Female Sex Workers Recently Infected with HIV-1 in Thailand. AIDS Res Hum Retroviruses. 2016 Jul;32(7):694-701. doi: 10.1089/AID.2015.0371. Epub 2016 Apr 19. PMID: 26892382 (SCI) 國際合作
6. Lin YC, Chu PY, Chang MY, Hsiao KL, Lin JH, Liu HF. Spatial Temporal Dynamics and Molecular Evolution of Re-Emerging Rabies Virus in Taiwan. Int J Mol Sci. 2016 Mar 17;17(3):392. doi: 10.3390/ijms17030392. PMID: 26999115 (SCI)
7. Hui-Wen Huang, Yao-Shen Chen, Jeff Yi-Fu Chen, Po-Liang Lu, Yung-Cheng Lin, Bao-Chen Chen, Li-Chiu Chou, Chu-Feng Wang, Hui-Ju Su, Yi-Chien Huang, Yong-Ying Shi, Hsiu-Lin Chen, Bintou Sanno-Duanda, Tsi-Shu Huang, Kuei-Hsiang Lin, Yu-Chang Tyan, Pei-Yu Chu*. Phylodynamic reconstruction of the spatiotemporal transmission and demographic history of coxsackievirus B2. BMC Bioinformatics 2015, 16:302 doi:10.1186 (SCI)
8. Guan-Ming Ke, Chin-Hsiang Ho, Meng-Jung Chiang, Bintou Sanno-Duanda, Cheng-Shu Chung, Maw-Yeong Lin, Yong-Ying Shi, Ming-Hui Yang, Yu-Chang Tyan, Pao-Chi Liao, Pei-Yu Chu*. Phylodynamic analysis of the canine distemper virus hemagglutinin gene. BMC Vet Res. 2015; 11: 164. (SCI)
9. Tsai MH, Lin KH, Lin KT, Hung CM, Cheng HS, Tyan YC, Huang HW, Sanno-Duanda B, Yang MH, Yuan SS, Chu PY*. Predictors for Early Identification of Hepatitis C Virus Infection. Biomed Res Int. 2015;2015:429290. doi: 10.1155/2015/429290. Epub 2015 Aug 27. PMID: 26413522 (SCI) IF:2.706, BIOTECHNOLOGY & APPLIED MICROBIOLOGY 53/153=32%
10. Pei-Yu Chu*, Yu-Chang Tyan, Yao-Shen Chen, Hsiu-Lin Chen, Po-Liang Lu, Yu-Hsien Chen, Bao-Chen Chen, Tsi-Shu Huang, Chu-Feng Wang, Hui-Ju Su, Yong-Ying Shi, Bintou Sanno-Duanda, Kuei-Hsiang Lin, Kazushi Motomura*. Transmission and Demographic Dynamics of Coxsackievirus B1. PLoS One. 2015 Jun 8;10(6):e0129272. doi: 10.1371 (SCI)
11. Yung-Cheng Lin, Po-Liang Lu, Kuei-Hsiang Lin, Pei-Yu Chu, Chu-Feng Wang, Jih-Hui Lin, Hsin-Fu Liu*. Molecular Epidemiology and Phylogenetic Analysis of Human Adenovirus Caused an Outbreak in Taiwan during 2011. PLoS One. 2015 May 18;10(5):e0127377 (SCI)
12. Ming-Hui Yang, Shyng-Shiou Yuan, Yi-Ling Chen, Pei-Yu Chu, Shiang-Bin Jong, Ying-Fong Huang, Chi-Yu Lu, Yi-Shan Lu, Po-Chiao Lin, Yu-Chang Tyan*. (2014, Feb). Mass Spectrometry in Clinical Diagnosis: A Preliminary Application in Tumor Cellular Proteomics for Biomarker Discovery.. J Anal Bioanal Tech, S2. 1-13.
13. Pei-Yu Chu and Chien-Fang Peng* (2014, Jan). The genetic environments of Transferable Plasmid-mediated blaCTX-M-3 Gene in Serratia marcescens Isolates. Japanese Journal of Infectious Diseases 2014;67(1):58-61. , 67(1):58-61. (SCI). IF:1.204,INFECTIOUS DISEASES 61/72=84.7%
14. Pei-Yu Chu, Guan-Ming Ke, Po-Chih Chen, Li-Teh Liu, Yen-Chun Tsa, Jih-Jin Tsai* Spatiotemporal Dynamics and Epistatic Interaction Sites in Dengue Virus Type 1: A Comprehensive Sequence-Based Analysis, PLOS ONE 2013;8:9-e74165 (1-11) (SCI). IF: 3.730 MULTIDISCIPLINARY SCIENCES = 7/56 = 12.5%
15. Yang MH, Yang YH, Lu CY, Jong SB, Chen LJ, Lin YF, Wu SJ, Chu PY, Chung TW, Tyan YC. (2012, Jul). Activity-dependent neuroprotector homeobox protein level in Alzheimer’s disease in Taiwanese . Genomic Medicine, Biomarkers, and Health Sciences, 4, 48-50.
16. Yang MH, Yang YH, Lu CY, Jong SB, Chen LJ, Lin YF, Wu SJ, Chu PY, Chung TW, Tyan YC. (2012, Apr). Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease. J Proteomics. , 2012 Jun 27;75(12):3617-29. IF:4.878, BIOCHEMICAL RESEARCH METHODS = 12/72 = 16.7%
17. Guan-Ming Ke, Kuei-Hsiang Lin, Po-Liang Lu, Yi-Chin Tung, Chu-Feng Wang, Liang-Yin Ke, Min-Sheng Lee, Pei-Chin Lin, Hui-Ju Su, Yi-Ying Lin, Tzu-Ping Huang, Jen-Ren Wang, Sheng-Yu Wang, Li-Ching Hsu, Pei-Yu Chu* Molecular epidemiology of Echovirus 30 in Taiwan, 1988–2008, Virus Genes 2011;42:2-178-188. IF=1.693 GENETICS & HEREDITY = 112/156 = 71.8%
18. Pei-Yu Chu*, Po-Liang Lu, Yu-Ling Tsai, Edward Hsi, Ching-Yuan Yao, Yu-Hsien Chen, Li-Ching Hsu, Sheng-Yu Wang, Ho-Sheng Wu, Yi-Ying Lin, Hui-Ju Su, Kuei-Hsiang Lin* Spatiotemporal phylogenetic analysis and molecular characterization of coxsackievirus A4, Infection, Genetics and Evolution 2011;11:6-1426-35. IF:3.086, INFECTIOUS DISEASES = 20/58 = 34%
19. M. H. Yang, R. R. Krishnamoorthy, S. B. Jong, P. Y. Chu, Y. H. Yang, W. C. Chen, S. C. J. Chen, A. Dibas, T. Yorio, T. W. Chung, Y. C. Tyan* Protein profiling of human non-pigmented ciliary epithelium cell secretome – the differentiation factors characterization for retinal ganglion cell-line, Journal of Biomedicine and Biotechnology 2011;1-1-28. IF:1.23 BIOTECHNOLOGY & APPLIED MICROBIOLOGY = 111/160=69%
20. M. H Yang, P. Y. Chu, S. C. J. Chen, T. W. Chung, W. C. Chen, L. B. Tan, W. C. Kan, H. Y. Wang, S. B. Su, Y. C. Tyan* Characterization of ADAM28 as a biomarker of bladder transitional cell carcinoma by urinary proteome analysis., Biochemical and Biophysical Research Communications 2011;411:1-714-720. (SCI) IF:20595 BIOPHYSICS = 38/73= 52%
21. Ke GM, Yu SW, Ho CH, Chu PY, Ke LY, Lin KH, Tsai YC, Liu HJ, Lin MY. (2010, Jan). Characterization of newly emerging Newcastle disease viruses isolated during 2002-2008 in Taiwan. Virus Res., 247–257. (SCI). IF:2.563 VIROLOGY=15/30=50%
22. Dai CY, Chuang WL, Hsieh MY, Huang JF, Lin YY, Chu PY, Hou NJ, Lin ZY, Chen SC, Hsieh MY, Wang LY, Yu ML* Human leukocyte antigen alleles and the response to pegylated interferon/ribavirin therapy in chronic hepatitis C patients., Antiviral Res 2010;85:2-396-402. IF:3.612, PHARMACOLOGY & PHARMACY =50/237=21.1%
23. Kuo-Hsiang Chuang, Shey-Cherng Tzou, Ta-Chun Cheng, Chien-Han Kao, Wei-Lung Tseng, Jentaie Shiea, Kuang-Wen Lia, Yun-Ming Wang,, Ya-Chen Chang, Bo-Jyun Huang, Chang-Jer Wu, Pei-Yu Chu, Steve Roffler, and Tian-Lu Cheng Measurement of Poly(ethylene glycol) by Cell-Based Anti-poly(ethylene glycol) ELISA, Analytical Chemistry 2010;82:6-2355–2362. IF:5.214CHEMISTRY, ANALYTICAL =3/70 =4.2%
24. Chu Pei-Yu; Ke Guan-Ming; Chen Yao-Shen; Lu Po-Liang; Chen Hsiu-Lin; Lee Min-Sheng; Chen Bao-Chen; Huang Tsi-Shu; Li Yu-Chen; Chou Li-Chiu; Wang Sheng-Yu; Lin Kuei-Hsiang. Molecular epidemiology of Coxsackievirus B3., INFECT GENET EVOL 2010;21:6-777–784 IF:3.223 INFECTIOUS DISEASES 14/57=24.6%
25. Jo-Chi Jao, Hsiang-Chin Lu, Hsin-Ying Lu, Yun-Ming Wang, Gin-Chung Liu, Li-Min Lin, Pei-Yu Chu, Shih-Hsie Chen, Po-Chou Chen* The Imaging Behavior of an MRI Contrast Agent [Gd(TTDA-BOM)]2- in a Mice Liver Tumor Model at 3 Tesla, Journal of Medical and Biological Engineering 2010;30:3-139-144 IF:0.42, ENGINEERING, BIOMEDICAL 62/69 = 89.9%
26. Chu PY*, Tsai YL, Chen HL, Ke GM, Hsu CY, Chen YT, Wang CF, Su HJ, Chou LC, Hsu LC, Lin KH. Coxsackievirus B4 in southern Taiwan: molecular epidemiology. J Clin Virol. 2009 May,45(1):16-22. (SCI)
27. Chu PY, Ke GM, Chang CH, Lin JC, Sun CY, Huang WL, Tsai YC, Ke LY, Lin KH. Molecular epidemiology of coxsackie A type 24 variant in Taiwan, 2000-2007. J Clin Virol. 2009 May,45(4):285-91. (SCI)
28. Cheng CM, Chu PY, Chuang KH, Roffler SR, Kao CH, Tseng WL, Shiea J, Chang WD, Su YC, Chen BM, Wang YM, Cheng TL. Hapten-derivatized nanoparticle targeting and imaging of gene expression by multimodality imaging systems. Cancer Gene Therapy 2009 Jan,16(1):83-90. (SCI)
29. Lin KH, Hwang KP, Ke GM, Wang CF, Ke LY, Hsu YT, Tung YC, Chu PY, Chen BH, Chen HL, Kao CL, Wang JR, Eng HL, Wang SY, Hsu LC, Chen HY. Evolution of EV71 genogroup in Taiwan from 1998 to 2005: An emerging of subgenogroup C4 of EV71. J Med Virol, 2006, 78(2): 254–62. (SCI)

研討會論文

1. Pei-Yu Chu*, Hui-Wen Huang, Yong-Ying Shi. Phylogenetic tree and network analysis for reconstructing evolutionary dynamics of coxsackievirus B5 and swine vesicular disease virus. 24 April 2017, The 27th European Congress of Clinical Microbiology and Infectious Diseases. ECCMID 2017. Vienna, Austria
2. 褚佩瑜, 施詠瑩, 林建精 . Phylodynamic analysis of coxsackievirus A24 variants by next-generation sequencing . The 26th European Congress of Clinical Microbiology and Infectious Diseases. Amsterdam . Netherlands . 08-Apr-2016~12-Apr-2016
3. Pei-Yu Chu*, Chien-Ching Lin, Yong-Ying Shi. . Molecular epidemiology of coxsackievirus B5. The 25th European Congress of Clinical Microbiology and Infectious Diseases. Copenhagen . Denmark . 25-Apr-2015~28-Apr-2015
4. Pei-Yu Chu*, Yu-Hsien Chen, Yong-Ying Shi . Spatiotemporal transmission and phylodynamics of coxsackievirus B1 . The 24th European Congress of Clinical Microbiology and Infectious Diseases . 巴賽隆納 . Spain . 10-May-2014~14-May-2014
5. J.Y. Zeng, C.C. Lin, P.Y. Chu* . Molecular epidemiology of coxsackievirus A24 variant in Taiwan: VP1 sequence-based analysis of 1985-2010 isolates . The 24th European Congress of Clinical Microbiology and Infectious Diseases . 巴賽隆納 . . 10-May-2014~14-May-2014
6. Y.Y. Shi, Y.C. Huang, P.Y. Chu* . Phylodynamic characterization of Coxsackievirus B2 . The 24th European Congress of Clinical Microbiology and Infectious Diseases . 巴賽隆納 . . 10-May-2014~14-May-2014
7. P.-Y. Chu1, G.-M. Ke2, Y.-C. Tsai3, J.-J. Tsai*3 . PHYLODYNAMIC RECONSTRUCTION AND MOLECULAR CHARACTERIZATION OF DENGUE VIRUS TYPE 1 . The 5th Congress of European Microbiologists . Leipzig . Germany . 21-Jul-2013~25-Jul-2013
8. 褚佩瑜*, 盧柏樑, 蔡玉玲, 眭致遠, 姚清源, 陳昱憲, 許麗卿, 王聖予, 吳和生, 林儀英, 蘇慧茹, 林貴香* . 南台灣腸病毒分子之流行病學 . 2011 兩岸熱帶醫學研討會 . 高雄 . . 26-May-2011~27-May-2011
9. 褚佩瑜*,林貴香 . 克沙奇B5型病毒之分子流行病學 . 第十屆華人檢驗醫學學術研討會 . 臺北 . . 05-Nov-2011~06-Nov-2011
10. 褚佩瑜* . 南台灣克沙奇病毒B1分子流行病學研究 . 第十屆華人檢驗醫學學術研討會 . 臺北 . . 05-Nov-2011~06-Nov-2011
11. Pei-Yu Chu, Guan-Ming Ke, Cheng-Hsien Chang, Jou-Chun Lin, Chung-Yi Sun, Wen-Loong Huang, Yen-Chin Tsai, Liang-Yin Ke, Kuei-Hsiang Lin* . MOLECULAR EPIDEMIOLOGY OF COXSACKIE A TYPE 24 VARIANT IN TAIWAN, 2000-2007 . FEMS 2009 - 3rd Congress of European Microbiologists . Gothenburg . Sweden . 28-Jun-2009~02-Jul-2009
12. Mei-Hua Tsai, Kuei-Hsiang Lin, Pei-Yu Chu, Kuan-Tsou Lin, Chi-Ming Hung,Kuo-Sin Lin . Epidemiology of Human T-lymphotropic virus I/II Among Blood Donors in Taiwan . ISBT( International Society of Blood Transfution ) . Nagoya . Japan . 14-Nov-2009~18-Nov-2009

得獎事蹟

• 科技部105年度補助大專校院獎勵特殊優秀研究人才
• 科技部103年度補助大專校院獎勵特殊優秀教學人才
• 101學年度優良教材成果獎勵 / 第三名
• 101學年度優良教材成果獎勵 / 佳作
• 101學年度教學優良教師
• 101系教學優良教師
• 101院（中心）級教學優良教師
• 科技部100年度補助大專校院獎勵特殊優秀教學人才
• 99學年度績優導師
• 99院級績優導師
• 98學年度優良教材成果獎勵
• 98系教學優良教師
• 97學年度教學優良教師
• 97學年度優良教材成果獎勵

專書著作

• 褚佩瑜等/吳俊忠總校閱(2014). 臨床微生物學－細菌與黴菌學：第十四章（第五版）五南文化
• 褚佩瑜(2013). 微生物學與免疫學 啟英文化
• 褚佩瑜(2012). 臨床細菌學(第五版) 藝軒圖書出版社
• 褚佩瑜(2011). 微生物學速攻(第二版) 藝軒圖書出版社
• 褚佩瑜(2011). 生物化學速攻(第三版) 藝軒圖書出版社
• 褚佩瑜(2009). 醫學寄生蟲學 藝軒圖書出版社
• 褚佩瑜(2006). 免疫學速攻 藝軒圖書出版社