蔡婉琪 副教授

學歷

• 成功大學基礎醫學研究所博士
• 高雄醫學院醫學技術學系學士

經歷

• 中山醫學大學醫學檢驗暨生物技術學系助理教授
• 美國俄亥俄州立大學藥理學院博士後研究

研究興趣

• 研究中草藥及小分子化合物於癌症治療上之潛力及作用機轉
  Evaluate the potential and decipher the mechanism of Chinese herbal medicine and chemical compounds in cancer treatment
• 找尋可供早期偵測大腸直腸癌之分子標記
  To identify the novel biomarkers for early detection in colorectal cancer

Publications

1. Lee YP*, Tsai WC*, Ko CJ*, Rao YK, Yang CR, Chen DR, Yang MH, Yang CC and Tzeng YM. Anticancer effects of eleven triterpenoids derived from Antrodia camphorata. 2012, Anticancer Research 32(7):2727-34. (SCI)
2. Lin YC, Wang WH, Tsai WC, Chen CC, Chen WC and Lee KF. Predicting the Early Invasiveness of Nasopharyngeal Mucosal Neoplasia After Radiotherapy by Narrow-Band Imaging: A Pilot Study. 2012, Head & Neck (In press) (SCI)
3. Lin YC, Wang WH, Lee KF, Tsai WC, Weng HH. Value of Narrow-Band Imaging Endoscopy in Early Mucosal Head and Neck Cancer. 2012, Head & Neck (In press) (SCI)
4. Grisdanurak, N, Akewaranugulsiri S, Futalan C, Tsai WC, Kan CC, Hsu CW, Wan MW. The Study of Copper Adsorption from Aqueous Solution using Crosslinked Chitosan Immobilized on Bentonite. 2012, Journal of applied polymer science 125(S2): E132–42 (SCI)
5. Tsai WC, Kan CC, Futalan C, Dalida MP, Wan MW. The Multi-Metals Adsorption of Single and Binary System using Chitosan Coated Bentonite Beads. 2011, Journal of Science and Technology 4(45):144-8.
6. Dalida MLP, Mariano AFV, Futalan CM, Kan CC, Tsai WC and Wan MW. Adsorptive removal of Cu(II) from aqueous solutions using non-crosslinked and crosslinked chitosan-coated bentonite beads. 2011, Desalination 275:154-9. (SCI)
7. Tsai WC, Tsai ST, Shen WH, Lin YC, Jin YT, Chao TL, Wu LW. Lack of modulatory function of coding nucleotide polymorphism S100A2_185G>A in oral squamous cell carcinoma. 2010, Oral Diseases 17(3):283-290. (SCI)
8. Tsai WC, Rao YK, Lin SS, Chou MY, Shen YT, Wu CH, Geethangili M, Yang CC, Tzeng YM. Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway. 2010, Bioorganic & Medicinal Chemistry Letters 15;20(20):6145-8. (SCI)
9. Wei S, Chuang HC, Tsai WC, Yang HC, Ho SR, Paterson AJ, Kulp SK, and Chen CS. Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the upregulation of β-TRCP. 2009, Mol Pharm 76:47-57. (SCI)
10. Tsai WC, Tsai ST, Jin YT, Wu LW. Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma. 2006, Mol Cancer Res 4:539-547. (SCI)
11. Tsai ST, Jin YT, Tsai WC, Wang ST, Lin YC, Chang MT, Wu LW. S100A2, a potential marker for early recurrence in early-stage oral cancer. 2005, Oral Oncol 41:349-357. (SCI)
12. Tsai WC, Tsai ST, Ko JY, Jin YT, Li C, Huang W, Young KC, Lai MD, Liu HS, Wu LW. The mRNA profile of genes in betel quid chewing oral cancer patients. 2004, Oral Oncol 40:418-26. (SCI)
13. Jih YJ, Lien WH, Tsai WC, Yang GW, Li C, Wu LW. Distinct regulation of genes by bFGF and VEGF-A in endothelial cells. 2001, Angiogenesis 4:313-21. (SCI)

Conference Publications

1. Wan-Chi Tsai. The anti-cancer potential and possible mechanism of clioquinol in pancreatic cancer. International Symposium on Pancreas Cancer 2012. Kyoto, Japan, 2012. (Poster)
2. Wan-Chi Tsai, Ching Gong Lin, Li Ting Tzeng, Zong-Shiow Chen. The antioxidant and anti-proliferative activity of the myrciaria cauliflora extract. 21st Asia Pacific Cancer Conference. Kuala Lumpur, Malaysia, 2011. (Poster)
3. Wan-Chi Tsai, Ching Gong Lin, Li Ting Tzeng, Zong-Shiow Chen. The antioxidant and anti-proliferation effects of lotus plumule extracts on oral squamous cell carcinoma cell lines. 2011 International Conference of Inflammation, Cancer, and Metabolic Disorders. Miaoli, Taiwan, 2011. (Poster)
4. Wan-Chi Tsai, Chi-Chuan Kan, Ibarra-Buscano, S., Maria L. Dalida, Meng-Wei Wan. Selectivity Sequence and Adsorption Mechanism of Multi-Metals in Aqueous Solution using Chitosan- Bentonite Composite Beads. International Conference on Challenges in Environmental Science & Engineering. Tainan, Taiwan, 2011. (Oral presentation)
5. Wan-Chi Tsai, Chi-Chuan Kan, Cybelle Futalan, Maria L. Dalida, Meng-Wei Wan. The multi-metals adsorption of single and binary system using chitosan coated bentonite beads. International Forum on Green Technology and Management (IFGTM). Da Nang, Vietnam, 2011. (Oral presentation)
6. Yen-Yu Liu, Wan-Chi Tsai. The Anti-cancer Potential of Clioquinol-derivatives in Pancreatic Cancer. The 26th Joint Annual Conference of Biomedical Sciences (JCSB). Taipei, Taiwan, 2011. (Poster)
7. Wan-Chi Tsai, Yew-Min Tzeng and Chi-Chiang Yang. The anti-tumor effects of cytotoxic triterpenes from Antrodia camphorata in oral carcinoma cells. The 4th World Congress of International Federation of Head and Neck Oncologic Societies (IFHNOS). Seoul, Korea, 2010. (Poster)
8. Wan-Chi Tsai, Shih-Shen Lin, Ming-Yung Chou, Madamanchi Geethangili, Yi-Ting Shen, Chih-Hao Wu, Yew-Min Tzeng and Chi-Chiang Yang. The Selective Apoptotic Cytotoxicity of Methylantcinate A from Antrodia Camphorata in Oral Cancer Cells. The 25th Joint Annual Conference of Biomedical Sciences (JCSB). Taipei, Taiwan, 2010. (Poster)
9. Wan-Chi Tsai, Chen-Hsun Tsai, Jing-Ru Weng, Samuel K. Kulp and Ching-Shih Chen. OSU-A9, an Indole-3-Carbinol derivative, is a new potential antitumor agent for advanced pancreatic cancer. The 100th American Association for Cancer Research (AACR). Denver, CO, U.S.A., 2009. (Poster)
10. Wan-Chi Tsai, Wen-Hao Shen, Sen-Tien Tsai, Li-Wha Wu. G182A polymorphism in S100A2 coding sequence: lack of association with the anti-tumor effect by S100A2 in oral cancer cells. The 24th Joint Annual Conference of Biomedical Sciences (JCSB). Taipei, Taiwan, 2009. (Poster)
11. Wan-Chi Tsai, Sen-Tien Tsai, Yin-Tai Jin, Li-Wha Wu. The tumor suppression role of S100A2 in human oral squamous carcinoma cells. The 21th Joint Annual Conference of Biomedical Sciences (JCSB). Taipei, Taiwan, 2006. (Oral presentation)
12. Wan-Chi Tsai, Sen-Tien Tsai, Li-Wha Wu. The tumor suppressor role of S100A2 in human epidermal carcinoma cells. The 96th American Association for Cancer Research (AACR). Anaheim, CA, U.S.A., 2005. (Poster)
13. Wan-Chi Tsai, Sen-Tien Tsai, Li-Wha Wu. Characterizing the molecular function of S100A2 in oral carcinogenesis. The 19th Joint Annual Conference of Biomedical Sciences (JCSB). Taipei, Taiwan, 2004. (Poster)
14. Wan-Chi Tsai, Sen-Tien Tsai, Li-Wha Wu. Profiling expression of genes in betel-quid chewing related oral cancers. The 4th Asian-Pacific Organization for Cell Biology Congress (APOCB). Taipei, Taiwan, 2002. (Poster)