王述綺 助理教授

shuchiwwang

Shu-Chi Wang, Assistant Professor

  • 研究室:濟世大樓CS607室
  • 單位電話:(07)312-1101 #2354
  • 電子信箱:shuchiwang@kmu.edu.tw

最高學歷(Education)

  • 國立清華大學 生醫工程與環境科學系 博士
    Ph.D. Department of Biomedical Engineering and Environmental Sciences.
    National Tsing Hua University, Taiwan

經歷 (Experience)

  • 高雄醫學大學附設醫院 健康管理中心 助理研究員 2012-2018
    Research Scientist, Health Management Center,
    Kaohsiung Medical University Hospital.

  • 美國德州西南醫學中心 放射腫瘤中心 博士後研究員 2011-2012
    Postdoctoral Fellow, Department of Radiation Oncology.
    University of Texas Southwestern Medical Center, Dallas, USA.

  • 美國紐約醫學大學 醫學院 訪問學者(科技部千里馬計劃) 2007
    Visiting Graduate Students, Department of Pathology.
    New York University of Medicine, New York, USA.

 

研究主題 (Research Interest)

·       

  • 病毒性肝細胞病變和相關肝癌之研究
     Study of viral-related cytopathic effect and hepatocellular carcinoma.

  • 腫瘤微環境的改變和療效的關係

    The correlation of tumor microenvironments alternation with treatment efficiency.

  • 細胞氧化壓力對DNA傷害和修復能力之探討

    Investigation of cellular oxidative DNA damage and repair ability.  

代表著作 (Publication)

1.    Huang C.F., Wang S.C., Yeh M.L., Huang C.I., Tsai P.C., Lin Z.Y., Chen S.C., Dai C.Y., Huang J.F., Chuang W.L., Chen A., Yu M.L., Association of serial serum major histocompatibility complex class I chain-related A measurements with hepatocellular carcinoma in chronic hepatitis C patients after viral eradication. J Gastroenterol Hepatol. 2018 Jun 22. doi: 10.1111/jgh.14359. (SCI, IF:3.483; 27/80 33.75% in GASTROENTEROLOGY & HEPATOLOGY )

2.    Lin K.H., Huang M.Y., Cheng W.C., Wang S.C., Fang S.H., Tu H.P., Su C.C., Hung Y.L., Liu P.L., Chen C.S., Wang Y.T., Li C.Y., RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment. Sci Rep. 2018 Feb 8;8(1):2672. (SCI, IF:4.122; 12/64 18.75% in MULTIDISCIPLINARY SCIENCES)

3.    Wang S.C., Lai K.R., Li C.Y., Chiang C.S., Yu G.Y., Naoya Sakamoto, Tu W.T., Hsieh M.H., Huang J.F., Chuang W.L., Dai C.Y., Yu M.L., The paradoxical effects of different hepatitis C viral loads on host DNA damage and repair abilities. PLoS ONE. 2017 Jan 4;12(1):e0164281. (SCI, IF:2.806; 15/64 23.4% in MULTIDISCIPLINARY SCIENCES)

4.    Huang C.F., Huang C.I., Yeh M.L., Wang S.C., Chen K.Y., Ko Y.M., Lin C.C., Tsai YS, Tsai PC, Lin ZY, Chen SC, Dai CY, Huang JF, Chuang WL, Yu ML. Diversity of the association of serum levels and genetic variants of MHC class I polypeptide-related chain A with liver fibrosis in chronic hepatitis C. Oncotarget. 2017 May 16;8(20):32618-32625. (SCI, IF:5.168; 44/217 20.28% in ONCOLOGY)

5.    Wang S.C., Yang J.F., Wang C.L., Huang C.F., Lin Y.Y., Chen Y.Y., Lo C.T., Lee P.Y., Wu K.T., Lin C.I., Hsieh M.H., Chuang H.Y., Ho C.K., Yu M.L., Dai C.Y., Distinct subpopulations of hepatitis C virus infectious cells with different levels of intracellular hepatitis C virus core protein. Kaohsiung J Med Sci. 2016 Oct;32(10):487-493. (SCI, IF:1.150; 103/128 80.5% in MEDICINE, RESEARCH & EXPERIMENTAL)

6.    Hung Y.L., Fang S.H., Wang S.C., Cheng W.C., Liu P.L., Su C.C., Chen C.S., Huang M.Y., Hua K.F., Shen K.H., Wang Y.T., Katsuhiko Suzuki, and Li C.Y., Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response. Sci Rep. 2017 Apr 11;7:46299. (SCI, IF:4.259; 10/64 15.6% in MULTIDISCIPLINARY SCIENCES)

7.    Hsieh M.H., Wang S.C., Hsieh M.Y., Huang C.F., Yeh M.L., Yang J.F., Chang K., Lin W.R., Lin C.Y., Chen T.C., Huang J.F., Dai C.Y., Tsai J.J., Chuang W.L., Yu M.L., Hepatitis D virus infections among injecting drug users with and without human immunodeficiency virus infection in Taiwan. Kaohsiung J Med Sci. 2016 Oct;32(10):526-530. (SCI, IF:1.150; 103/128 80.5% in MEDICINE, RESEARCH & EXPERIMENTAL)

8.    Lu M.Y., Huang C.I., Dai C.Y., Wang S.C., Hsieh M.Y, Hsieh M.H., Liang P.C., Lin Y.H., Hou N.J., Yeh M.L., Huang C.F., Lin Z.Y., Chen S.C., Huang J.F., Chuang W.L., Yu M.L., Elevated on-treatment levels of serum IFN-gamma is associated with treatment failure of peginterferon plus ribavirin therapy for chronic hepatitis C. Sci Rep. 2016 Mar 11;6:22995. (SCI, IF:4.259; 10/64 15.6%  in MULTIDISCIPLINARY SCIENCES)

9.    Hsieh M.H., Hsieh M.Y., Huang C.F., Yeh M.L., Wang S.C., Yang J.F., Chang K., Lin W.R., Lin C.Y., Chen T.C., Huang J.F., Dai C.Y., Tsai J.J., Chuang W.L., Yu M.L., Anti-HIV seropositivity was related to HBsAg seropositivity among injecting drug users in Taiwan. Kaohsiung J Med Sci. 2016 Feb;32(2):96-102. (SCI, IF:1.150; 103/128 80.5%  in MEDICINE, RESEARCH & EXPERIMENTAL)

10.  Lee K.J., Saha J., Sun J., Fattah K.R., Wang S.C., Jakob B., Chi L., Wang S.Y., Taucher-Scholz G., Davis A.J., Chen D.J., Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase. Nucleic Acids Res. 2016 Feb 29;44(4):1732-45. (SCI, IF:10.162; 14/286 4.9% in BIOCHEMISTRY & MOLECULAR BIOLOGY)

11.  Yu C.F., Lin C.M., Wang S.C., Chen F.H., Hong J.H., Tsai C.S., Yang Y.C., Chiang C.S., Effects of pre-irradiation and SDF-1 suppression on the progression of murine astrocytoma cells grown in different stromal beds. International Journal of Radiation Biology. 2014 Dec; 90(12):1162-8. (SCI, IF:1.992; 3/33 9.1% in NUCLEAR SCIENCE & TECHNOLOGY)

12.  Wang S.C., Yu C.F., Hong J.H., Tsai C.S., Chiang C.S., Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis. PLoS ONE. 2013 Aug 5;8(8):e69182 (SCI, IF:2.806; 15/64 23.4%  in MULTIDISCIPLINARY SCIENCES)

13.  Wang S.C., Hong J.H., Hsueh C., Chiang C.S., Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model. Laboratory Investigation. 2012. Jan;92(1):151-62. (SCI, IF:4.857; 16/128 12.5% in PATHOLOGY)

14.  Chiang C.S., Fu S.Y., Wang S.C., Yu C.F., Chen F.H., Lin C.M., Hong J.H., Irradiation promotes an m2 macrophage phenotype in tumor hypoxia. Frontiers in Oncology. 2012 Aug;2:89. (IF:4.66)

15.  Li C.Y., Chiang C.S., Cheng W.C., Wang S.C., Chang H.Z., Chen C.R., Shu W.Y., Tsai M.L., Hseu R.S., Chang C.W., Huang C.Y., Fang S.H., Hsu I.C., Gene expression profiling of dendritic cells in different physiological stages under Cordyceps sinensis treatment. PLoS ONE. 2012 Jul;7(7):e40824. (SCI, IF:2.806; 15/64 23.4% in MULTIDISCIPLINARY SCIENCES)

16.  Huang F.Y., Lee T.W., Kao C.H., Chang C.H., Zhang X., Lee W.Y., Chen W.J., Wang S.C., Lo J.M., Imaging, autoradiography, and biodistribution of (188)Re-labeled PEGylated nanoliposome in orthotopic glioma bearing rat model. Cancer Biotherapy & Radiopharmaceuticals. 2011 Dec;26(6):717-25.  (SCI, IF:1.689; 75/126 59.5% in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)

17.  Wang S.C., Wu C.C., Wei Y.Y., Hong J.H., Chiang C.S. Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells. International Journal of Radiation Biology. 2011 Apr;87(4):432-42. (SCI, IF:1.992; 3/33 9.1% in NUCLEAR SCIENCE & TECHNOLOGY)

18.  Li C.Y., Chao L. K., Wang S.C., Chang H. Z., Tsai M. L., Fang S. H., Liao P.C., Ho C.L., Chen S.T., Cheng W.C., Chiang C.S., Kuo Y.H., Hua K.F., Hsu I.C., Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells. Journal of Cellular Physiology. 2011 Sep;226(9):2338-49. (SCI, IF:4.080; 16/84 19.0% in PHYSIOLOGY.)

19.  Luo W.Y., Shih Y.S., Lo W.H., Chen H.R., Wang S.C., Wang C.H., Chien C.H., Chiang C.S., Chuang Y.J., Hu Y.C., Baculovirus vectors for antiangiogenesis-based cancer gene therapy. Cancer Gene Therapy. 2011 Sep;18(9):637-45. (SCI, IF:3.652; 38/158 24.1% in BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

20.  Luo W.Y., Shih Y.S., Hung C.L., Lo K.W., Chiang C.S., Lo W.H., Huang S.F., Wang S.C., Yu C.F., Chien C.H., Hu Y.C., Development of the hybrid Sleeping Beauty-baculovirus vector for sustained gene expression and cancer therapy. Gene Therapy. 2012 Aug;19(8):844-51. (SCI, IF:3.110; 49/158 31.0% in BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

21.  Méndez O., Zavadil J., Esencay M., Lukyanov Y., Santovasi D., Wang S.C., Newcomb E. W., Zagzag D., Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres. Molecular Cancer. 2010, 1(9):133. (SCI, IF:6.204; 36/286 12.6% in BIOCHEMISTRY & MOLECULAR BIOLOGY)

22.  Newcomb E.W., Lukyanov Y., Kawashima N., Alonso-Basanta M., Wang S.C., Liu M., Jure-Kunkel M., Zagzag D., Demaria S. and Formenti S.C., Radiotherapy Enhances Antitumor Effect of Anti-CD137 Therapy in a Mouse Model for Glioma. Radiation Research. 2010, 173(4):426-432. (SCI, IF:2.539; 24/84 28.6% in BIOLOGY.)

23.  Liu W.C., Wang S.C., Tsai M.L., Chen M.C., Wang Y.C., Hong, J.H., McBride W.H., Chiang C.S., Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis - a Chinese herbal medicine. Radiation Research. 2006, 166(6):900-907. (SCI, IF:2.539; 24/84 28.6% in BIOLOGY.)

24.  Wang S.C., Chung J.G., Chen C.H., Chen S.C., 2- and 4-Aminobiphenyls induce oxidative DNA damage in human hepatoma (Hep G2) cells via different mechanisms. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 2006, 29;593(1-2):9-21. (SCI, IF:2.581; 58/161 36% in BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

25.  Wang S.C., Chen C.S., Chen S.C, Flow cytometric measurement of reactive oxygen species production from Hep G2 cell treated with Benzidine and its analogs. Bulletin of Association of Laboratory Medicine R.O.C. 2003, 18(4): 110-115.

 
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