吳慶軒 教授

Ching-Shuang Wu

Ching-Shuang Wu, Professor

  • 研究室: 濟世大樓 CS605室
  • 聯絡電話:(07)312-1101 ext.2352
  • 電子信箱:m785034@kmu.edu.tw

學歷

  • 高雄醫學大學醫學研究所博士 (1998~2004)
  • 高雄醫學大學醫學研究所碩士 (1993~1996)
  • 高雄醫學院醫學技術學系學士 (1983~1987)

經歷

  • 高雄醫學大學醫學檢驗生物技術學系 教授 (2014~)
  • 高雄醫學大學醫學檢驗生物技術學系 副教授 (2008~2014)
  • 高雄醫學大學附設中和紀念醫院 高級醫事檢驗師
  • 高雄醫學大學健康科學院總務組 研教組 組長
  • 高雄醫學大學醫學檢驗生物技術學系 助理教授 (2005~2008)
  • 高雄醫學大學醫學技術學系講師 (1996~2005)
  • 高雄醫學大學醫學技術學系助教 (1989~1996)

學術專長

免疫學、臨床血清免疫學、細胞生物學、細胞培養、皮膚免疫學

研究領域

  • 化學致癌相關研究
  • 臨床檢驗醫學研究
  • 白斑病人致病與治療機轉之研究
  • 不同波長光線對於細胞生理效應調控之研究
  • 糖尿病病人傷口癒合不良之機轉探討
  • 蟹足腫病人致病機轉與治療方法之開發與研究

期刊論文著作 (*corresponding author)

  1. Ching-Shuang Wu, Chia-Li Yu, Chung-Hsing Chang, Wen-Rei Kuo, Hsiang-Ju Lin and Hsin-Su Yu. Effect and correlation of serum total IgE, eosinophil granule cationic proteins and sensitized allergens in atopic dermatitis patients with or without rhinitis. Kaohsiung J Med Sci 18: 229-235, 2002.
  2. Shu-Ping Swen, Ching-Shuang Wu and Hsin-Su Yu. Effects of helium-neon laser on human melanoma cell migration . Biomedical Engineering Application, Basis and Communication 14: 243-250, 2002.
  3. CC E Lan, WC Tsai, CS Wu, CL Yu, HS Yu. Psoriatic patients with arthropathy show significant expression of free HLA class I heavy chains on circulating monocytes: a potential role in the pathogenesis of psoriatic arthropathy . Brit J Dermatol 151: 24-31, 2004. (SCI)
  4. Wu C-S, Yu C-L, Wu C-S, Lan C-CE, Yu H-S. Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes. Exp Dermatol 13: 755-763, 2004. (SCI)
  5. Lan CC, Yu HS, Wu CS, Tsai KB, Wen CH, Chen GS. Pigmented eccrine poroma with enhanced endothelin-1 expression: implications for mechanism of hyperpigmentation. Brit J Dermatol 152: 1070-1072, 2005. (SCI)
  6. Lan CC, Wu CS, Cheng CM, Yu CL, Chen GS, Yu HS. Pigmentation in basal cell carcinoma involves enhanced endothelin-1 expression. Exp Dermatol 14: 528-534, 2005. (SCI)
  7. Lan CC, Chen GS, Chiou MH, Wu CS, Chang CH, Yu HS. FK506 promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes: possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo. Brit J Dermatol 153: 498-505, 2005. (SCI)
  8. Lan CC, Yu HS, Wu CS, Kuo HY, Chai CY, Chen GS. FK506 inhibits tumour necrosis factor-alpha secretion in human keratinocytes via regulation of nuclear factor-kappaB. Brit J Dermatol 153: 725-732, 2005. (SCI)
  9. Lan CC, Wu CS, Chiou MH, Hsieh PC, Yu HS. Low-energy helium-neon laser induces locomotion of the immature melanoblasts and promotes melanogenesis of the more differentiated melanoblasts: recapitulation of vitiligo repigmentation in vitro. J Invest Dermatol 126: 2119-2126, 2006. (SCI)
  10. Lan CC, Wu CS, Tsai PC, Chen GS. Diagnostic role of soluble fas ligand secretion by peripheral blood mononuclear cells from patients with previous drug-induced blistering disease: a pilot study. Acta Dermato-Venereologica 86: 215-218, 2006. (SCI)
  11. Wu CS, Lan CC, Chiou MH, Yu HS. Basic fibroblast growth factor promotes melanocyte migration via increased expression of p125(FAK) on melanocytes. Acta Dermato-Venereologica 86: 498-502, 2006. (SCI)
  12. Lan CC, Yu HS, Wu CS, Chen GS. Immotile acral melanocytes? Brit J Dermatol 155: 1300-1301, 2006. (SCI)
  13. Lan CC, Lin CL, Wu CS, Chai CY, Chen WT, Chen GS. Treatment of idiopathic prurigo nodularis in Taiwanese patients with low-dose thalidomide. J Dermatol 34: 237-242, 2007. (SCI)
  14. Hu SC, Chen GS, Wu CS, Lan CC. Serum tissue polypeptide antigen correlating with clinical course in a patient with mycosis fungoides: a potential disease marker? Brit J Dermatol 157: 423-425, 2007. (SCI)
  15. Lan CC, Yu HS, Huang SM, Wu CS, Chen GS. FK506 induces interleukin-6 secretion from UVB irradiated cultured human keratinocytes via p38 mitogen-activated protein kinase pathway: implication on mechanisms of tacrolimus-induced skin irritation. J Dermatol Sci 48: 225-228, 2007, (SCI)
  16. Wu CS, Lan CC, Wang LF, Chen GS, Wu CS, Yu HS. Effects of psoralen plus ultraviolet A irradiation on cultured epidermal cells in vitro and patients with vitiligo in vivo. Brit J Dermatol 156: 122-129, 2007. (SCI)
  17. Tsai J, Chen GS, Lu YW, Wu CS, Lan CC. Late-onset Behcet's disease does not correlate with indolent clinical course: report of seven Taiwanese patients. J Eur Acad Dermatol 22: 596-600, 2008, (SCI)
  18. Hu SC, Chen GS, Wu CS, Chai CY, Chen WT, Lan CC. Pigmented eccrine poromas: expression of melanocyte-stimulating cytokines by tumour cells does not always result in melanocyte colonization. J Eur Acad Dermatol 22: 303-310, 2008, (SCI)
  19. Lan CC, Wu CS, Chen GS. Pretreatment tumour necrosis factor-alpha secretions from peripheral blood mononuclear cells of psoriatic patients do not correlate with rapid clinical response: urgent need for prognostic parameters. J Eur Acad Dermatol 22: 398-399, 2008, (SCI)
  20. Hu SC, Chen GS, Lu YW, Wu CS, Lan CC. Cutaneous metastases from different internal malignancies: a clinical and prognostic appraisal. J Eur Acad Dermatol 22: 735-740, 2008, (SCI)
  21. Lan CC, Liu IH, Fang AH, Wen CH, Wu CS*. Hyperglycemic Conditions Decreases Cultured Keratinocyte Mobility: Implications on Impaired Wound Healing in Diabetic Patients. Brit J Dermatol 159: 1103-1115, 2008. (SCI)
  22. Lan CC, Feng WW, Lu YW, Wu CS, Hung ST, Hsu HY, Yu HS, Ko YC, Lee CH, Yang YH, Chen GS. Hand eczema among University Hospital nursing staff: identification of high-risk sector and impact on quality of life. Contact Dermatitis 59: 301-306, 2008. (SCI)
  23. Hu SC, Chen GS, Wu CS, Chai CY, Chen WT, Lan CC. Rates of cutaneous metastases from different internal malignancies: Experience from a Taiwanese medical center. J Am Acad Dermatol. 60: 379-387, 2009. (SCI)
  24. Cheng-Che E. Lan, Ching-Shuang Wu, Hsuan-Yu Kuo, Shu-Mei Huang, Gwo-Shing Chen. Hyperglycemic Conditions Hamper keratinocyte Locomotion via Sequential Inhibition of Distinct Pathways: New Insights on Poor Wound Closure of Diabetic Patients. Brit J Dermatol. 160: 1206-1214, 2009. (SCI)
  25. CCE Lan, CS Wu, GS Chen, HS Yu. Helium-neon laser and topical tacrolimus combination therapy: novel treatment option for vitiligo without additional photocarcinogenic risks. J Eur Acad Dermatol 23: 344-345, 2009. (SCI)
  26. Lan CC, Ko YC, Tu HP, Wu CS, Lee CH, Wu CS, Yu HS. Association study between keratinocyte-derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor. Br J Dermatol. 160: 1180-1187, 2009. (SCI)
  27. Lan CC, Wu CS, Chiou MH, Chiang TY, Yu HS. Low-energy helium-neon laser induces melanocyte proliferation via interaction with type IV collagen: visible light as a therapeutic option for vitiligo. Br J Dermatol. 161: 273-280, 2009. (SCI)
  28. Lan CC, Lee CH, Lu YW, Lin CL, Chiu HH, Chou TC, Hu SC, Wu CY, Kim YY, Yang HJ, Chen YC, Wu CS, Hsu HY, Shieh SL, Yu HS, Ko YC, Chen GS. Prevalence of adult atopic dermatitis among nursing staff in a Taiwanese medical center: A pilot study on validation of diagnostic questionnaires. J Am Acad Dermatol. 2009; 61: 806-812. (SCI)
  29. Lan CC, Yu HS, Huang SM, Wu CS, Kuo HY, Lee CH, Lin CS, Chen GS. Topical tacrolimus has a limited direct effect on ultraviolet B-irradiated keratinocytes: implications for its photocarcinogenic potential. Clin Exp Dermatol. 2010; 35: 173-179. (SCI)
  30. Lan CC, Wu CS, Chen GS, Yu HS. FK506 (topical tacrolimus) and Enothothelin Combined Treatment Induces Mobility of Melanoblasts: New Insights of Follicular Vitiligo Repigmentation Induced by Topical Tacrolimus on Sun-Exposed Skin. Br J Dermatol. 2011; 164: 490-496. (SCI)
  31. Yu WT, Yu HS, Wu CS, Lee CH, Cheng YC, Lin WT, Chen GS, Lan CC. Noninvasive cutaneous blood flow assessment as a response predictor for visible light therapy on segmental vitiligo: A prospective pilot study. Br J Dermatol. 2011; 164: 759-764.
  32. Lan CC, Tu HP, Lee CH, Wu CS, Ko YC, Yu HS, Lu YW, Li WC, Chen GS. Hand dermatitis among university hospital nursing staff with or without atopic eczema: assessment of risk factors. Contact Dermatitis. 2011; 64: 73-79.
  33. Lan CC, Wu CS, Huang SM, Kuo HY, Wu IH, Wen CH, Chai CY, Ai-Hui F, Chen GS. High glucose environment inhibits p38MAPK signaling and reduces human beta-defensin 3 expressions in keratinocytes. Mol Med 2011; 17: 771-779.
  34. Wu CS, Lan CC, Yu HS. Narrow-band UVB irradiation stimulates the migration and functional development of vitiligo-IgG antibodies-treated pigment cells. J Eur Acad Dermatol Venereol 2012; 26: 456-464.
  35. Lan CC, Tu HP, Wu CS, Ko YC, Yu HS, Lu YW, Li WC, Chen YC, Chen GS. Distinct SPINK5 and IL-31 polymorphisms are associated with atopic eczema and non-atopic hand dermatitis in Taiwanese nursing population. Exp Dermatol. 2012 ; 20: 975-979..
  36. Lan CC, Wu SB, Wu CS, Shen YC, Chiang TY, Wei YH, Yu HS. Induction of primitive pigment cell differentiation by visible light (helium-neon laser): a photoacceptor-specific response not replicable by UVB irradiation. J Mol Med (Berl). 2012; 90: 321-330.
  37. Lan CC, Ko YC, Yu HS, Wu CS, Li WC, Lu YW, Chen YC, Chin YY, Yang YH, Chen GS. Methotrexate Reduces the Occurrences of Cerebrovascular Events among Taiwanese Psoriatic Patients: A Nationwide Population-Based Study. Acta Derm Venereol. 2012 Feb 1. [Epub ahead of print]
  38. Lan CC, Wu CS, Huang SM, Kuo HY, Wu IH, Liang CW, Chen GS. High Glucose Environment Reduces Human Beta-Defensin 2 Expressions in Human Keratinocytes: Implications for Poor Diabetic Wound Healing.Br J Dermatol. 2012 Jan 27. [Epub ahead of print]
  39. Ching-Shuang Wu, Cheng-Che E. Lan, Hsuan-Yu Kuo, Chee-Yin Chai, Wan-Tzu Chen, Gwo-Shing Chen. Differential Regulation of Nuclear Factor-Kappa B Subunits on Epidermal Keratinocytes by Ultraviolet B and Tacrolimus. Kaohsiung J Med Sci 2012.
  40. Ching-Shuang Wu, Pei-Hsuan Wu, Ai-Huai Fang, Cheng-Che E Lan. FK506 inhibits the enhancing effects of transforming growth factor-β1 on collagen expression and TGF-β/Smad signaling in keloid fibroblasts: Implication for new therapeutic approach. Br J Dermatol 2012; 167: 532-541.
  41. Yung-Shun Su, Hsin-Su Yu, Wan-Chen Li, Ying-Chin Ko, Gwo-Shing Chen, Ching-Shuang Wu, Yi-Wei Lu, Yi-Hsin Yang, Cheng-Che E. Lan. Psoriasis as Initiator or amplifier of the Systemic Inflammatory March: Impact on Development of Severe Vascular Events and Implications for Treatment Strategy. J Eur Acad Dermatol Venereol 2012; [Epub ahead of print]
  42. Yi-Ying Chin, Hsin-Su Yu, Wan-Chen Li, Ying-Chin Ko, Gwo-Shing Chen, Ching-Shuang Wu, Yi-Wei Lu, Yi-Hsin Yang, Cheng-Che E. Lan. Arthritis as an important determinant for psoriatic patients to develop severe vascular events in Taiwan: A nation-wide study. JEADV, 2012.
  43. Hu SC, Lin CL, Lu YW, Chen GS, Yu HS, Wu CS, Lan CC. Lymphopaenia, Anti-Ro/Anti-RNP Autoantibodies, Renal Involvement and Cyclophosphamide Use Correlate with Increased Risk of Herpes Zoster in Patients with Systemic Lupus Erythematosus. Acta Derm Venereol. 2012 Sep 17. doi: 10.2340/00015555-1454. [Epub ahead of print]
  44. Lan CC, Ko YC, Yu HS, Li WC, Wu CS, Lu YW, Yang YH, Chen GS. Psoriatic patients with diabetes are prone to develop digestive organ cancers: A population-based study in Taiwan. J Dermatol Sci. 2012 Aug 28. [Epub ahead of print]
  45. Chen, Yin-Chun; Tu, Hung-Pin; Wu, Ching-Shuang; Ko, Ying-Chin; Yu, Hsin-Su; Lu, Yi-Wei; Li, Wan-Chan; Chen, Gwo-Shing; Lan, Cheng-Che Association between non-atopic hand eczema with interleukin-13 gene polymorphism in Taiwanese nursing population. Exp Dermatol (letters to editors) In press.2012

研討會發表論文

  1. C.S. Wu, H.S. Yu: Different Effects of PUVA and Narrow-band UVB on Human Melanocytes. 28th Ammual Meeting of the Chinese Dermatological Society, Taipei, Sep 11~12, 2002.
  2. H.S. Yu, C.S. Wu: Narrow-band UVB stimulates proliferation and migration in cultured melanocytes. 34th Symposium of European Society for Dermatological Research, Vienna-Austria, Sep. 9~11, 2004.
  3. 吳慶軒、藍正哲、柯玫如、余幸司: Effects of narrow-band UVB irradiation on proliferation、migration and melanogenesis in melanoblasts. 台灣皮膚科醫學會第30屆年會暨學術討論會,榮民總醫院,11/13~14, 2004
  4. C.C. E. Lan, C.S. Wu, C.M. Cheng, G.S. Chen, H.S. Yu. Enhanced Expression of Endothelin-1 in Pigmented Basal Cell Carcinoma: lmplication for the mechanism of hyperpigmentation. 30th Ammual Meeting of the Chinese Dermatological Society, Taipei, Nov 13~14, 2004.
  5. 吳慶軒、藍正哲、吳君平、余幸司: Basic fibroblast growth factor promotes melanocyte migration via increased expression of p125FAK on melanocytes. 台灣皮膚科醫學會第31屆年會暨學術討論會November 11-13, 2005, Tzu Chi university, Hualien.
  6. J. Tsai, C.C. E. Lan, C.S. Wu, G.S. Chen :A pilot study of using soluble FAS ligand for identification of offending drug in patients with previous drug-induced blistering disease. The 23rd Meeting of Pacific Skin Research Club. November 11-13, 2005, Tzu Chi university, Hualien.
  7. C.C. Lan, H.S. Yu, C.S. Wu, G.S. Chen: FK506 inhibits tumor necrosis factor-?secretion in human keratinocytes via regulation of nuclear factor kappa B. The 23rd Meeting of Pacific Skin Research Club. November 11-13, 2005, Tzu Chi university, Hualien.
  8. C.S. Wu, C.H. Ho, C.C. E. Lan, M.H. Chiou, W.P. Hu, J.J. Wang, H.S. Yu: Helium-neon laser induces melanoblast migration via enhanced focal adhesion kinase phosphorylation. The 23rd Meeting of Pacific Skin Research Club, November 11-13, 2005, Tzu Chi university, Hualien.
  9. 吳慶軒、藍正哲、陳國熏、吳介山、余幸司: Effects of PUVA Irradiation on Cultured Epidermal Cells in vitro and Vitiligo Patients in vivo PUVA.台灣皮膚科醫學會第32屆年會暨學術討論會,馬偕紀念醫院,11/18~19, 2006.
  10. 吳慶軒、劉依欣、藍政哲: High glucose decreased cultured human keratinocyte migration and proliferation: implications on pathomechanisms of impaired wound healing in diabetic patients. 第15屆細胞及分子生物新知研討會,屏東,2/1~2/3, 2007.
  11. 吳慶軒、藍政哲、陳國熏、余幸司: Effects of Combination of Narrow-band UVB and Vitiligo IgG Antibody on Migration and Functional Development of Melanoblast. 台灣皮膚科醫學會第33屆年會暨學術討論會,成大醫院,11/17~18, 2007.
  12. 藍政哲、吳慶軒、陳國熏、余幸司: Protective Anti-Kertinocyte IgG Antibodies in Vitiligo Patients. 台灣皮膚科醫學會第33屆年會暨學術討論會,成大醫院,11/17~18, 2007.
  13. 藍政哲、吳慶軒、陳國熏、余幸司: FK506 induces differentiation of melanoblasts via protein kinase activation. 台灣皮膚科醫學會第34屆年會暨學術討論會,長庚醫院,11/22~23, 2008.
  14. 吳慶軒、郭忠民: Hyperglycemic suppress the skin innate immunity: implication on impaired wound healing in diabetic patients. 第17屆細胞及分子生物新知研討會. 高雄墾丁, 2009.2.11~2009.2.13.
  15. 吳慶軒、王于禎: Effects of FK506 on TGF-beta 1 stimulated normal and keloid fibroblasts proliferation, migration, and collagen synthesis. 第17屆細胞及分子生物新知研討會. 高雄墾丁, 2009.2.11~2009.2.13.
  16. Cheng-Che Lan, Ching-Shuang Wu, Shi-Bei Wu, Gwo-Shing Chen, Yao-Hui Wei, Hsin-Su Yu. Effects of helium-neon laser on melanoblast differentiation: Focusing on mitochondrial biogenesis and antioxidant enzyme. 台灣皮膚科醫學會第35屆年會暨學術討論會,高雄醫學大學皮膚科,11/21~22, 2009.
  17. Cheng-Che E. Lan, Ching-Shuang Wu, Gwo-Shing Chen: Excimer light for vitiligo treatment: An in vivo and vitro investigation. 台灣皮膚科醫學會第36屆年會暨學術討論會,台灣大學皮膚科,11/20~21, 2010.
  18. Hsin-Su Yu, Cheng-Che E. Lan, Ching-Shuang Wu, Gwo-Shing Chen, Yao-Hui Wei: Effects of helium-neon laser on melanoblast differentiation: Focusing on mitochondrial biogenesis and antioxidant enzymes. SID 2010 Annual Meeting, May 5-8, 2010, Atlanta, Georgia, USA.
  19. 吳慶軒,吳佩璇: The inhibitory effect of FK506 on TGF-β1 induced fibroblast proliferation, migration and collagen synthesis: implications of therapeutic approach for keloid. 第26屆生物醫學聯合學術年會,國防醫學院,3/19~20,2011.

專書著作

  1. Hsin-Su Yu, Cheng-Che E. Lan, Ching-Shuang Wu. Segmental Vitiligo: a model for understanding the recapitulation of repigmentation In: Vitiligo Taieb A and Picardo M Eds. Springer, New York, 2010.

 

 

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