Inventions & Patents

Patent No. I359196: Early detection of Borrelia burgdorferi sensu lato, the PCR primer pair and diagnostic method. (50%) 

Patent No. I580782: Biochemistry reactive material and device for eliminating low-density lipoprotein (LDL) and method for treating blood or plasma ex vivo to eliminate low-density lipoprotein therein (25%) (20170501~20350810)

Patent No. CN106434619B: 生化反应材料与装置以及体外处理血液或血浆的方法(25%) (20200324~20351123)

Patent No. US20170044516A1: Biochemistry reactive material and device for eliminating low-density lipoprotein (LDL) and method for treating blood or plasma ex vivo to eliminate low-density lipoprotein therein (25%) (20170216~20200130)

Patent No. US20150148410A1: Identification of specific apolipoprotein epitopes on circulating atherogenic LDL. WO/2013/036926 (50%) (20150528~)

Patent No. US20190010483A1 Method for ex vivo treating blood or plasma (25%) (20190110~)

Publications

Publications (*: corresponding author)

1. Hung SC, Chan TF, Chan HC, Wu CY, Chan ML, Jhuang JY, Tan JQ, Mei JB, Law SH, Ponnusamy VK, Chan HC*, Ke LY*. Lysophosphatidylcholine impairs the mitochondria homeostasis leading to trophoblast dysfunction in gestational diabetes mellitus. Antioxidants. 2024, 13(8), 1007.
2. Cheng CC, Chu PH, Huang HW, Ke GM, Ke LY*, Chu PY*. Phylodynamic and epistatic analysis of Coxsackievirus A24 and its variant. Viruses-Basel. 2024 Aug, 16(8), 1267.
3. Shashikumar U, Saraswat A, Deshmukh K, Hussain CM, Chandra P, Tsai PC, Huang PC, Chen YH, Ke LY, Lin YC, Chawla S, Ponnusamy VK. Innovative technologies for the fabrication of 3D/4D smart hydrogels and its biomedical applications - A comprehensive review. Adv Colloid Interface Sci. 2024 Jun;328:103163.
4. Chang H, Kuo CF, Yu TS, Ke LY, Hung CL, Tsai SY. Increased risk of chronic fatigue syndrome following infection: a 17-year population-based cohort study. J Transl Med. 2023 Nov 11;21(1):804.
5. Shashikumar U, Joshi S, Srivastava A, Tsai PC, Shree KDS, Suresh M, Ravindran B, Hussain CM, Chawla S*, Ke LY*, Ponnusamy VK**. Trajectory in biological metal-organic frameworks: Biosensing and F sustainable strategies-perspectives and challenges. Int J Biol Macromol. 2023 Oct 9:127120. [IF=8.2; CHEMISTRY, APPLIED].
6. Chen PK, Chang JH, Ke LY, Kao JK, Chen CH, Yang RC, Yoshimura T, Ito E, Tsai JJ. Advanced Detection Method for Dengue NS1 Protein Using Ultrasensitive ELISA with Thio-NAD Cycling. Viruses-Basel. 2023 Sep 8;15(9):1894.  
7. Law SH, Ke CC, Chu CS, Liu SH, Weng MC, Ke LY*, Chan HC*. SPECT/CT imaging for tracking subendothelial retention of electronegative low-density lipoprotein in vivo. Int J Biol Macromol. 2023 Aug 2;250:126069. [IF=8.2; CHEMISTRY, APPLIED].
8. Tsao CH, Hsieh WC, Lin FJ, Yang RY, Chang MT, Apaya MK, Shyur LF, Ke LY, Zouboulis CC, Liu FT. The Critical Role of Galectin-12 in Modulating Lipid Metabolism in Sebaceous Glands. J Invest Dermatol. 2023 Jun;143(6):913-924.e4.
9. Law SH, Chan HC*, Ke GM, Kamatam S, Marathe GK, Ponnusamy VK, Ke LY*. Untargeted Lipidomic Profiling Reveals Lysophosphatidylcholine and Ceramide as Atherosclerotic Risk Factors in Apolipoprotein E Knockout Mice. Int J Mol Sci. 2023 Apr 9;24(8):6956.
10. Cheng CC, Ke GM, Chu PY*, Ke LY*. Elucidating the Implications of Norovirus N- and O-Glycosylation, O-GlcNAcylation, and Phosphorylation. Viruses-Basel. 2023 Mar 21;15(3):798.
11. Tsao CH, Hsieh WC, Yang RY, Lo YH, Tu TJ, Ke LY, Zouboulis CC, Liu FT. Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2. Glycobiology. 2022 Feb 26;32(1):73-82.
12. Chu PY, Huang HW, Boonchan M, Tyan YC, Louis KL, Lee KM, Motomura K*, Ke LY*. Mass Spectrometry-Based System for Identifying and Typing Norovirus Major Capsid Protein VP1. Viruses-Basel. 2021, 13(11), 2332.
13. Lin YS, Liu CK, Lee HC, Chou MC, Ke LY, Chen CH, Chen SL. Electronegative very low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice. Sci Rep. 2021 Mar 16;11(1):6013.
14. Kakino A, Fujita Y, Ke LY, Chan HC, Tsai MH, Dai CY, Chen CH, Sawamura T. Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects. J Lipid Res. 2021;62:100001.
15. Shin SJ, Chen CH, Kuo WC, Chan HC, Chan HCB, Lin KD, Ke LY*. Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved. Metabolism - Clinical and Experimental. 2020 Dec;113:154403. [IF=13.93; ENDOCRINOLOGY & METABOLISM].
16. Ke LY†, Law SH†, Mishra VK, Parveen F, Chan HC, Lu YH, Chu CS*. Molecular and cellular mechanisms of electronegative lipoproteins in cardiovascular diseases. Biomedicines. 2020 Nov 29;8(12):550.
17. Chan HC†, Ke LY†, Lu HT, Weng SF, Chan HC, Law SH, Lin IL, Chang CF, Lu YH, Chen CH, Chu CS*. An increased plasma level of apoCIII-rich electronegative high-density lipoprotein may contribute to cognitive impairment in Alzheimer's disease. Biomedicines 2020 Nov 26;8(12):542.
18. Liang HL, Cheng PW, Lin HL, Hao CL, Ke LY, Chou HY, Tseng YH, Yen HW, Shen KP. Extract of pre-germinated brown rice protects against cardiovascular dysfunction by reducing levels of inflammation and free radicals in a rat model of type II diabetes. Journal of Functional Foods Dec 2020, 75, 104215
19. Marathe GK, Chaithra VH, Ke LY, Chen CH. Effect of acyl and alkyl analogs of platelet-activating factor on inflammatory signaling. Prostaglandins Other Lipid Mediat. 2020 Dec;151:106478
20. Lee HC, Shin SJ, Huang JK, Lin MY, Lin YH, Ke LY, Jiang HJ, Tsai WC, Chao MF, Lin YH. The role of postprandial very-low-density lipoprotein in the development of atrial remodeling in metabolic syndrome. Lipids Health Dis. 2020 Sep 22;19(1):210.
21. Chu CS, Law SH, Lenzen D, Tan YH, Weng SF, Ito E, Wu JC, Chen CH, Chan HC*, Ke LY*. Clinical significance of electronegative low-density lipoprotein cholesterol in atherothrombosis. Biomedicines 2020 Jul 30;8(8):254.
22. Ke LY*, Chan HC, Chen CC, Chang CF, Lu PL, Chu CS, Lai WT, Shin SJ, Liu FT, Chen CH*. Increased APOE glycosylation plays a key role in the atherogenicity of L5 low-density lipoprotein. FASEB J 2020 Jul;34(7):9802-9813.
23. Chan HC, Chan HCB, Liang CJ, Lee HC, Su H, Lee AS, Shiea J, Tsai WC, Ou TT, Wu CC, Chu CS, Dixon RA, Ke LY*, Yen JH*, and Chen CH*. Role of low-density lipoprotein in early vascular aging associated with systemic lupus erythematosus. Arthritis Rheumatol. 2020 Jun;72(6):972-984. [IF=13.3; RHEUMATOLOGY].
24. Chen CH, Ke LY, Chan HC, Chu CS, Lee AS, Lin KD, Lee MY, Hsiao PJ, Chen CH, Shin SJ. Electronegative low-density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade. J Diabetes Investig. 2020 May;11(3):535-544.
25. Mishra VK†, Shih HH†, Parveen F, Lenzen D, Ito E, Chan TF*, Ke LY*. Identifying the therapeutic significance of mesenchymal stem cells. Cells 2020 May 6;9(5):1145.
26. Lin HL, Lin SH, Shen KP, Chan HC, Tseng YH, Yen HW, Law SH, Ke LY*. Efficiency comparison of PGBR extract and γ-oryzanol in antioxidative stress and anti-inflammatory properties against metabolic syndrome. J Food Biochem. 2020 Feb;44(2):e13129.
27. Parveen F†, Bender D†, Law SH, Mishra VK, Chen CC, Ke LY*. Role of ceramidases in sphingolipid metabolism and human diseases. Cells. 2019 Dec 4;8(12):1573.
28. Lia CL, Chu CH, Lee HC, Chou MC, Liu CK, Chen CH, Ke LY, Chen SL. Immunoregulatory effects of very low-density lipoprotein from healthy individuals and metabolic syndrome patients on glial cells. Immunobiology 2019 Sep;224(5):632-637.
29. Iha K, Inada M, Kawada N, Nakaishi K, Watabe S, Tan YH, Shen C, Ke LY, Yoshimura T, Ito E*. Ultrasensitive ELISA developed for early diagnosis. Diagnostics 2019 Jul 18; 9(3), pii: E78.
30. Shiou YL, Lin HT, Ke LY, Wu BN, Shin SJ, Chen CH, Tsai WC, Chu CS, Lee HC. Very low-density lipoproteins of metabolic syndrome modulates STIM1, suppresses store-operated calcium entry, and deranges myofilament proteins in atrial myocytes. J Clin Med. 2019 Jun 20;8(6):881.
31. Chen CH, Lin KD, Ke LY, Liang CJ, Kuo WC, Lee MY, Lee YL, Hsiao PJ, Hsu CC, Shin SJ. O-GlcNAcylation disrupts STRA6-retinol signals in kidneys of diabetes. Biochim Biophys Acta-Gen Subj. 2019 Jun;1863(6):1059-1069.
32. Yamakado S, Cho H, Inada M, Morikawa M, Jiang YH, Saito K, Nakaishi K, Watabe S, Takagi H, Kaneda M, Nakatsuma A, Ninomiya M, Imachi H, Arai T, Yoshimoto T, Murao K, Chang JH, Chen SM, Shih YC, Zeng MJ , Ke LY, Chen CH, Yoshimura T, Miura T, Ito E*. Urinary Adiponectin as A New Diagnostic Index for Chronic Kidney Disease Due to Diabetic Nephropathy. BMJ Open Diabetes Research & Care 2019 May 30;7(1):e000661.
33. Chen FC, Shen KP, Ke LY, Lin HL, Wu CC, Shaw SU*. Flavonoids from Camellia sinensis (L.) O. Kuntze seed ameliorates TNF-a induced insulin resistance in HepG2 cells, Saudi Pharm J. 2019 May;27(4):507-516.
34. Law SH†, Chan ML†, Marathe GK, Parveen F, Chen CH, Ke LY*. An updated review of lysophosphatidylcholine metabolism in human diseases. Int J Mol Sci. 2019 Mar 6;20(5):1149. [311 Citations as of Sep 2023, highly cited paper]
35. Hao CL, Lin HL, Ke LY, Yen HW, Shen KP*. Pre‐germinated brown rice extract ameliorates high‐fat diet‐induced metabolic syndrome. J Food Biochem. 2019 Mar;43(3):e12769.
36. Chu CS†, Chan HC†, Tsai MH, Stancel N, Lee HC, Cheng KH, Tung YC, Chan HCB, Wang CY, Shin SJ, Lai WT, Yang CY, Dixon RA, Chen CH*, Ke LY*. Range of L5 LDL levels in healthy adults and L5’s predictive power in patients with hyperlipidemia or coronary artery disease. Sci Rep. 2018 Aug 8;8(1):11866.
37. Wang YC†, Lee AS†, Lu LS†, Ke LY, Chen WY, Dong JW, Lu J, Chen ZP, Chu CS, Chan HC, Kuzan TY, Tsai MH, Hsu WL, Dixon RAF, Sawamura T, Chang KC*, Chen CH*. Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. Aging Cell. 2018 Aug;17(4):e12792.
38. Lee CH, Chu CS, Tsai HJ, Ke LY, Lee HC, Yeh JL, Chen CH, Wu BN. Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells. Chem Biol Interact. 2018 Jan 5;279:171-176.
39. Ke LY, Chan HC, Chan HCB, Kalu FCU, Lee HC, Lin IL, Jhuo SJ, Lai WT, Tsao CR, Sawamura T, Dixon RA, Chen CH, Chu CS*, Shin SJ*. Electronegative low-density lipoprotein L5 induces adipose tissue inflammation associated with metabolic syndrome. J Clin Endocrinol Metab 2017 Dec 1;102(12):4615- 4625.
40. Akyol S*, Lu J, Akyol O, Akcay F, Armutcu F, Ke LY*, Chen CH. The role of electronegative low-density lipoprotein in cardiovascular diseases and its therapeutic implications. Trends in Cardiovasc Med. 2017 May;27(4):239-246.[IF=9.3; CARDIAC & CARDIOVASCULAR SYSTEMS].
41. Ke LY, Chang JG, Chang CS, Hsieh LL, Liu TC. Rapid screening for deleted form β-thalassemia by real-time quantitative PCR. J Clin Lab Anal. 2017 Jan;31(1). doi: 10.1002/jcla.22019. Epub 2016 Aug 16.
42. Chu CS, Ke LY, Chan HC, Chan HCB, Chen CC, Cheng KC, Lee HC, Kuo HF, Chang CT, Sheu SH, Chen CH, Lai WT. The Four Statin Benefit Groups Defined by The 2013 ACC/AHA New Cholesterol Guideline are Characterized by Increased Plasma Levels of Electronegative LDL. Acta Cardiol Sin. 2016 Nov;32(6):667-675.
43. Chen CH, Ke LY, Chan HC, Lee AS, Lin KD, Chu CS, Lee MY, Hsiao PJ, Hsu C, Chen CH*, Shin SJ*. Electronegative low-density lipoprotein induces renal apoptosis and fibrosis: STRA6 signaling involved. J Lipid Res. 2016 Aug;57(8):1435-46.
44. Ke LY†, Chan HC†, Chen CC, Lu J, Marathe GK, Chu CS, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH*, Chen CH*. Enhanced sphingomyelinase activity in apolipoprotein B100 contributes to the atherogenicity of electronegative LDL. J Med Chem. 2016 Feb 11;59(3):1032-40. [IF=7.3; CHEMISTRY, MEDICINAL].
45. Lee HC, Lin HT, Ke LY, Wei C, Hsiao YL, Chu CS, Lai WT, Shin SJ, Chen CH, Sheu SH, Wu BN. VLDL from metabolic syndrome individuals enhanced lipid accumulation in atria with association of susceptibility to atrial fibrillation. Int J Mol Sci. 2016 Jan 20;17(1). 
46. Stancel N, Chen CC, Ke LY, Chu CS, Lu J, Sawamura T, Chen CH*. Interplay between CRP, atherogenic LDL, and LOX-1 and its potential role in the pathogenesis of atherosclerosis. Clin Chem. 2016 Feb;62(2):320-7. PMID: 26607724.
47. Tung YC, Ke LY, Lu PL, Lin KH, Lee SC, Lin YY, Chou LC, Tsai WC. Comparison of the Roche COBAS AmpliPrep/COBAS TaqMan HIV-1 test v1.0 with v2.0 in HIV-1 viral load quantification. Kaohsiung J Med Sci. 2015 Apr;31(4):188-93.
48. Tung YC, Ke LY, Tsai WC, Lin KH, Tsai SM, Wang CF, Lee HF, Su HJ, Lu PL. The development of a beacon-based real-time PCR for cytomegalovirus and its application in immunocompromised patients. Clin Lab. 2014;60(11):1895-901.
49. Ke LY†, Stancel N†, Bair H, Chen CH*. The underlying chemistry of electronegative LDL’s atherogenicity. Curr Atheroscler Rep. 2014;16:428.
50. Tung YC, Ke LY, Tsai SM, Lu PL, Tsai WC. High seroprevalence of human herpesvirus 8 infection in patients with systemic lupus erythematosus. Int J Rheum Dis. 2013 Dec;16(6):709-14.
51. Chan HC†, Ke LY† (co-first), Chu CS, Lee AS, Shen MY, Cruz MA, Hsu JF, Cheng KH, Chan HC, Lu J, Lai WT, Sawamura T, Sheu SH, Yen JH*, Chen CH*. Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood. 2013;122:3632-3641. [IF=20.3; HEMATOLOGY].
52. Tung YC, Lu PL, Ke LY, Tsai WC. CMV Infection and Pregnancy. Curr Obstet Gynecol Rep (2012) 1:216-222; 1(4). DOI:10.1007/s13669-012-0028-1.
53. Ke GM, Lin KH, Lu PL, Tung YC, Wang CF, Ke LY, Lee MS, Lin PC, Su HJ, Lin YY, Huang TP, Wang JR, Wang SY, Hsu LC, Chu PY. Molecular epidemiology of Echovirus 30 in Taiwan, 1988-2008. Virus Genes. 2011 Apr;42(2):178-88.
54. Ke LY, Engler DA, Lu J, Matsunami RK, Chan HC, Wang GJ, Yang CY, Chang JG, Chen CH*. Chemical composition–oriented receptor selectivity of L5, a naturally occurring atherogenic low-density lipoprotein. Pure Appl Chem. 2011;83:1731-1740.
55. Chan HC, Ke LY, Liu CC, Chang LL, Tsai WC, Liu HW, Yen JH. Increased expression of suppressor of cytokine signaling 1 mRNA in patients with rheumatoid arthritis. Kaohsiung J Med Sci. 2010 Jun;26(6):290-8.
56. Chan HC, Ke LY, Chang LL, Liu CC, Hung YH, Lin CH, Li RN, Tsai WC, Liu HW, Yen JH. Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus. Lupus. 2010 May;19(6):696-702.
57. Ke GM, Yu SW, Ho CH, Chu PY, Ke LY, Lin KH, Tsai YC, Liu HJ, Lin MY. Characterization of newly emerging Newcastle disease viruses isolated during 2002-2008 in Taiwan. Virus Res. 2010 Feb;147(2):247-57.
58. Chu PY, Ke GM, Chang CH, Lin JC, Sun CY, Huang WL, Tsai YC, Ke LY, Lin KH. Molecular epidemiology of coxsackie A type 24 variant in Taiwan, 2000-2007. J Clin Virol. 2009 Aug;45(4):285-91.
59. Chen CH, Dixon RAF, Ke LY, Willerson JT. Vascular progenitor cells in diabetes mellitus: Roles of Wnt signaling and negatively charged LDL. Circ Res. 2009;104:1038-1040. PMID:19423862. [IF=20.1; CARDIAC AND CARDIOVASCULAR SYSTEMS].
60. Tung YC, Lin KH, Chiang HC, Ke LY, Chen YH, Ke GM, Chen TC, Chou LC, Lu PL. Molecular epidemiology of dengue virus serotype 2 in the Taiwan 2002 outbreak with envelope gene and nonstructural protein 1 gene analysis. Kaohsiung J Med Sci. 2008 Aug;24(8):398-407.
61. Tung YC, Lin KH, Chang K, Ke LY, Ke GM, Lu PL, Lin CY, Chen YH, Chiang HC. Phylogenetic study of dengue-3 virus in Taiwan with sequence analysis of the core gene. Kaohsiung J Med Sci. 2008 Feb;24(2):55-62.
62. Tsai JJ, Sun HY, Ke LY, Tsai KS, Chang SY, Hsieh SM, Hsiao CF, Yen JH, Hung CC, Chang SC. Higher seroprevalence of Entamoeba histolytica infection is associated with human immunodeficiency virus type 1 infection in Taiwan. Am J Trop Med Hyg. 2006 Jun;74(6):1016-9.
63. Ke GM, Cheng HL, Ke LY, Ji WT, Chulu JL, Liao MH, Chang TJ, Liu HJ. Development of a quantitative Light Cycler real-time RT-PCR for detection of avian reovirus. J Virol Methods. 2006 Apr;133(1):6-13.
64. Hsu MC, Tsai PY, Chen KT, Li LH, Chiang CC, Tsai JJ, Ke LY, Chen HY, Li SY. Genotyping of Chlamydia trachomatis from clinical specimens in Taiwan. J Med Microbiol. 2006 Mar;55(Pt 3):301-8.
65. Lin KH, Hwang KP, Ke GM, Wang CF, Ke LY, Hsu YT, Tung YC, Chu PY, Chen BH, Chen HL, Kao CL, Wang JR, Eng HL, Wang SY, Hsu LC, Chen HY. Evolution of EV71 genogroup in Taiwan from 1998 to 2005: an emerging of subgenogroup C4 of EV71. J Med Virol. 2006 Feb;78(2):254-62.

2025 Activities

2025.03.26 I-PaMTech 2025 [Philippines] 

2025.03.17-21 Students from Ehime Prefectural University of Health Sciences visit KMU

2025.02.26 Dr. HP Tsai from NCKU

2025.02.19-21 Dr. Daniel from the University Hospital of Zürich

2025.02.15 Students' English presentation competition: the topic was "Innovative Application of Artificial Intelligence in Medical Laboratory". Presented by Po-Cheng Hung.

2025.01.23 Daniela from the University of Cologne

2025.01.22 2025 MLSB cup

2025.01.21 RMT

2024 Activities

2024.12.12 X'mas party

2024.12.06 MT white coat ceremony

2024.11.16 MT meeting

2024.11.09 Award

2024.10.19 Alumni

2024.10.15-18 ICBL 2024

2024.10.14 Dr. Abdel from the Florey, University of Melbourne.

2024.09 Students visit Univ. of Cologne.

2024.08 Students visit Waseda Univ.

2024.07.29 Visit Chula Univ with students.

2024.07.09 Prof. Ito from Waseda Univ., and Prof Virakul from Chula Univ.

2024.06.28-29 2024 TSMS.

2024.06.25 2024 Professor Stephen Blanksby from Queensland University of Technology.

2024.06.17 2024 Students from Mahidol Univ and Chula Univ.

2024.06.08 2024 Commencement

2024.06.04 Students from Chula University

2024.05.12 You Shan Ngui, Best Presentation Award

2024.05.03~05 STEM competition

2024.04.01~04 Dr. Dai, from the Department of Cell Biology and Neuroscience, Rutgers University, and Dr. Lu from Ferring Pharmaceuticals

2024.02. Günter from the Department of Biochemistry, University of Cologne

2024.02.06~08.02 Daniela from the Department of Biochemistry, University of Cologne, and 2024.03.10~03.17 Nao and Aika from the Department of Medical Technology, Ehime Prefectural University of Health Sciences

2024.03.16 You Shan Ngui, Best Presentation Award at 2024年醫學檢驗學生論壇

2024.02.23 With Prof. Marathe at the University of Mysore

2024.02.17~02.21 With Prof. Schwarz (Institute of Biochemistry, University of Cologne) at KMU

2024.01.30 With Dr. Dai at the Center for Integrative Proteomics Research CIPR of Rutgers University

2024.01.29 With Dr. Carman at the Rutgers Center for Lipid Research

2024.01.22 With Dr. Tzongshi Lu at Harvard University

2023 Activities

2023.12.26 X'mas party

2023.12.26 Journal Club

2023.12.22 White coat ceremony

2023.12.13 Dr. Tzongshi Lu (Harvard University, USA)

2023.11.20 Dr. Daniel Bender's talk (University Hospital of Zurich, Switzerland)

2023.11.19 Group Tour (Tainan)

2023.11.18 Dinner with Dr. Daniel Bender (University Hospital of Zurich, Switzerland) and Dr. Tewin Tencomnao (Chulalongkorn University, Thailand)

2023.11.18 Tour with Professor Etsuro Ito (Waseda University, Japan)

2023.10.21 42nd MLSB anniversary-Symposium

2023.10.21 42nd MLSB anniversary-Dinner party

2023.10.16 The 69th KMU anniversary: received the 2022 KMU Outstanding Faculty Research Award (RPI)

2023.10.02~2023.10.05 the 63rd International Conference of Lipid Research (ICBL 2023).

2023.07.17~2023.08.19 Students of MLSB-KMU joined the internship program at the Faculty of Allied Health Sciences, Chulalongkorn University, Thailand.

2023.07.25~2023.08.07 Professor Ke and Chan visited the Faculty of Allied Health Sciences, Chulalongkorn University, Thailand.

2023.07.01~2023.07.31 Two students (Nahathai Ngamsopee and Yanida Fangkoch) from the Faculty of Allied Health Sciences, Chulalongkorn University, Thailand joined an internship program at the MLSB-KMU.

2023.07.07~2023.07.22 Professor Ke, Assistant Professor Chan and two MLSB-KMU students (Shao-Chi Hung & SHi Hui Law) visited the Cambridge Innovation Center and the Lab Central in Boston, USA.

2023.07.07~2023.07.22 Professor Ke, Assistant Professor Chan and two MLSB-KMU students (Shao-Chi Hung & SHi Hui Law) visited Institute for Quantitative Biomedicine and the Department of Cell Biology & Neuroscience, Rutgers university New Brunswick.

2023.07.01~2023.07.31 Associate Professor Dr. Panan Ratthawongjirakul from the Faculty of Allied Health Sciences, Chulalongkorn University, Thailand, visited Medical Laboratory Science and Biotechnology, College of Health Sciences, KMU.

2023.07.01~2023.07.04 Professor Ke, Assistant Professor Chan and six MLSB-KMU students attended the 2nd Taiwan Lipid Research Summit (TLRS) at New Taipei.

2023.06.02~2023.06.04 The 2023 International symposium on Biosciences for Human Health, KMU.

2023.05.31~2023.06.05 AG Professor Günter Schwarz from the Institute for Biochemistry, University of Cologne gave two special talks at the KMU symposium. 1. Cysteine Metabolism in Health and Disease: The central role of H2S biology，2. Inhibitory synapses formation by phase separation in health and disease.

2023.05.31~2023.06.05 Visiting Professor Etsuro Ito from Department of Biochemistry of Waseda University gave two special talks at the KMU symposium. 1: RNA interference silencing with ultrasensitive ELISA for E7 protein changes in HPV cultured cells, 2: Gastric cancer cell-derived exosomal GRP78 enhances angiogenesis upon stimulation of vascular endothelial cells.

2023.05.30 MT108 the 38th MLSB-KMU graduation ceremony.

2023.05.09 Dr. Pranjal Chandra from Indian Institute of Technology (BHU), Varanasi, India visited KMU and gave special talk at a mini symposium. The topic was "Nanobioengineering for Medical Diagnosis".

2023.04.13-2023.04.21 Professor Ke visited Professor Etsuro Ito at Waseda University for students’ internship program and discussed the Dual Degree Program between two schools.

2023.04.14 Dr. Wen-Hui Lien from de Duve Institute, Université catholique de Louvain / FNRS visited KMU and gave two special talks. 1: 離台赴美轉歐的研究之路; 2: Roles of ROR2 in skin development, stem cell maintenance and tumorigenesis

2023.02.23 The Delegates from Mahidol University, Thailand visited KMU for collaborations.

2023.02.03 第21屆全國大專院校醫技盃

2022 Activities

2022.12.12~2022.12.15 Dr. Wanchai Assavalapsakul from Chulalongkorn University, Thailand visited MLSB-KMU for research collaboration and collaborative teaching.

2022.11.13~2022.12.15 Ting-Chieh Lai, Hsiang-Yu Wang and Guan-Jhu Chen from MLSB-KMU went to Professor Etsuro Ito’s laboratory in the Department of Biochemistry, Waseda University for Overseas Internship Program.

2022.12.04 Dr. Tanapat Palaga, Dr. Sita Virakul from Chulalongkorn University, Thailand visited MLSB-KMU for research collaboration and gave special talk to our faculty members and students.

2022.12.1~2022.12.4 Professor Ke and students attended the 2022 HealthCare Expo Taiwan.

2022.11.9~2022.12.4 Professor Ke and Ph.D. student Shi Hui Law from department of MLSB-KMU were invited to visit University of Cologne, Germany again for research collaborations.

2022.11.30. Professor Ke attended the Society for Free Radical Research-Taiwan (SFRR-Taiwan) and gave a talk entitled "Role of electronegative low-density lipoprotein and lysophosphatidylcholine in atherosclerotic caridiovascular diseases".

2022.10.26~2022.11.27 I-Pei Chen from KLSB-KMU went to Professor Guenter Schwarz’s laboratory at the Institute for Biochemistry, University of Cologne for the Overseas Internship Program.

2022.11.18 White Coat Ceremony 

2022.11.14 Dr. Siriphan Saeng-aroon from Ministry of Public Health, Thailand gave special talks to our faculty members and students.

2022.11.05~2022.11.13 Professor Ke visited Professor Schwarz’s laboratory in the Institute for Biochemistry, University of Cologne for research collaboration.

2022.11.8~2022.11.12 Ms. Kanako Iha, Ms. Akane Sato from the master program of Waseda University, Japan came to KMU for overseas internship program.

2022.11.06~2022.11.08 Students Shi Hui Law and Ting-Chieh Lai from department of Medical Laboratory Science participated the Cell Symposium: Multifaceted Mitochondria in Spain for poster presentation.

2022.09.26 Professor Ke visited the Gene Target Crop. 柯良胤教授帶5名系學會幹部至達易特基因科技股份有限公司企業參訪，並專訪董事長陳怡芳博士/醫技系友。

2022.07.30-2022.09.18 Students Shi Hui Law and Shao-Chi Hung from Medical Laboratory Science and Biotechnology joined the Oversea MLSB Internship program for research collaboration.

2022.08.12-2022.09.13 Professor Ke visited Professor Schwarz’s laboratory in the Institute for Biochemistry, University of Cologne for research collaboration.

2022.07.03~2022.07.05 The first Taiwan Lipid Research Summit (TLRS)

2023.05.30 MT108 the 38th MLSB-KMU graduation ceremony.

Earlier Activities

2021.10.16 40th ann

2021.10.15 Special talks by Professor Guenter Schwarz from Cologne University, Germany. Topics: Molybdenum cofactor deficiency: The journey of finding a treating for a rare inborn error in metabolism  

2021.10.15 Special talks by Ph.D. cadidate CY Fu from Cologne University, Germany. Topics: Metabolic interaction of systeine dioxygenase and sulfite oxidase in systeine catabolism

2021.06.25 Special talks by Professor Gopal K. Marathe from Mysore University, India. Topics: Effect of acyl and alkyl analogs of platelet-activating factor on inflammatory signaling

2021.06.24 Special talks by Professor Gopal K. Marathe from Mysore University, India. Topics: Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils

2021.03.01~2021.03.05 Liang-Yin Ke gave a talk at the 9th International Singapore Lipid Symposium – Lipid Oxidation Section. Topics: Specifying the Clinical Significance of Electronegative Low-density Lipoprotein in Atherothrombosis. The organizer of this event was Prof. Markus R Wenk from the National University of Singapore, Singapore.

2021.02.19 Liang-Yin Ke gave a talk “Atherosclerosis and electronegative LDL” to Professor Gopal K Marathe, Mysore University, India.

20201120 Shi Hui Law's Lightening talk for session three Virtual podium Asia pacific - metabolomics and lipidomics

20201113 Yong Hong Tan's Lightening talk for session two Virtual podium Asia pacific - metabolomics and lipidomics

20201030 舉辦「應用質譜科技於精準醫學工作坊」，專家演講講題為高解析質譜儀(Q-TOF)在臨床醫學上的應用；講者 : 詹華蓁、江佳穎

20190601 Graduate ceremony

20190129 Professor Schwarz

20190129 Professor Lu

20190129 Professor Marathe

20190128 Professor Schwarz

20190110 BioTech Final Presentation

20181227 Professor Ito

20181119 Daniel from Cologne University

20181009~12 BCS2018

20181003-20181007 Abisko, Kiruna

20180817~20180921 Cologne U

20180726~20180831 Waseda U

20180708 Gopal教授、蕭明熙教授、張權發教授蒞校演講

20180118~20180209 Cologne U, Germany

20171222 International students

Laboratory Members

Laboratory Members

Ph.D. student: Shao-Chi Hung

Master Students: Jia-Bin Mei, Ting-Chieh Lai, huei-Lin Wang, Hira Qumar, Yi-Wen Huang, You Shan Ngui, Yi-An Chang.

Bachelor Students: Shih-Han Huang, Chieh-Ju Wen.

Graduate Students

(畢業) Ph.D. Students: Shi Hui Law, Ching-Han Tsao

(畢業) Master Students: Hsiao-Ting Lu, Shih-Han Huang, Shi Hui Law, Liu-Fang Wang, Hui-Wen Huang, Yong Hong Tan, Bo-Xuan Yao, I-Pei Chen, Chia-Chi Cheng, Shao-Chi Hung, Hsin-Yi Tsai, Chia-Ying Wu

2023.06 Shao-Chi Hung, Hsin-Yi Tsai, Chia-Ying Wu (Master), Yi-Wen Huang, You Shan Ngui, Yi-An Chang (Bachler)

2024.06 Shao-Chi Hung (Master)

Hung SC, Chan TF, Chan HC, Wu CY, Chan ML, Jhuang JY, Tan JQ, Mei JB, Law SH, Ponnusamy VK, Chan HC*, Ke LY*. Lysophosphatidylcholine impairs the mitochondria homeostasis leading to trophoblast dysfunction in gestational diabetes mellitus. Antioxidants. 2024, 13(8), 1007.

2024.06 Chia-Chi Cheng (Master)

Cheng CC, Chu PH, Huang HW, Ke GM, Ke LY*, Chu PY*. Phylodynamic and epistatic analysis of Coxsackievirus A24 and its variant. Viruses-Basel. 2024 Aug, 16(8), 1267.

Cheng CC, Ke GM, Chu PY*, Ke LY*. Elucidating the implications of norovirus N- and O-glycosylation, O-GlcNAcylation, and phosphorylation. Viruses-Basel. 2023 Mar 21;15(3):798.

2023.06 Dr. Shi Hui Law (Doctoral)

Law SH, Ke CC, Chu CS, Liu SH, Weng MC, Ke LY*, Chan HC*. SPECT/CT imaging for tracking subendothelial retention of electronegative low-density lipoprotein in vivo. Int J Biol Macromol. 2023 Aug 2;250:126069.

Law SH, Chan HC*, Ke GM, Kamatam S, Marathe GK, Ponnusamy VK, Ke LY*. Untargeted Lipidomic Profiling Reveals Lysophosphatidylcholine and Ceramide as Atherosclerotic Risk Factors in apolipoprotein E Knockout Mice. Int J Mol Sci. 2023 Apr 9;24(8):6956.

2023.06 Cheng CC, Jia-Bin Mei (Bachler)

2022.06 Shao-Chi Hung (Bachler)

202106 Liu-Fang Wang, Yong Hong Tan (Master)

20200605 David Lenzen (Bachler)

1. Chu CS, Law SH, Lenzen D, Tan YH, Weng SF, Ito E, Wu JC, Chen CH, Chan HC, Ke LY. Clinical Significance of Electronegative Low-Density Lipoprotein Cholesterol in Atherothrombosis. Biomedicines. 2020 Jul 30;8(8):254. doi: 10.3390/biomedicines8080254. PMID: 32751498
2. Mishra VK, Shih HH, Parveen F, Lenzen D, Ito E, Chan TF, Ke LY. Identifying the Therapeutic Significance of Mesenchymal Stem Cells. Cells. 2020 May 6;9(5):1145. doi: 10.3390/cells9051145. PMID: 32384763

20190601 Shi Hui Law (Master), Yong Hong Tan, Chieh Shen (Bachler)

1. Parveen F, Bender D, Law SH, Mishra VK, Chen CC, Ke LY. Role of Ceramidases in Sphingolipid Metabolism and Human Diseases. Cells. 2019 Dec 4;8(12):1573. doi: 10.3390/cells8121573. PMID: 31817238
2. Law SH, Chan ML, Marathe GK, Parveen F, Chen CH, Ke LY. An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases. Int J Mol Sci. 2019 Mar 6;20(5):1149. doi: 10.3390/ijms20051149. PMID: 30845751 
3. Iha K, Inada M, Kawada N, Nakaishi K, Watabe S, Tan YH, Shen C, Ke LY, Yoshimura T, Ito E. Ultrasensitive ELISA Developed for Diagnosis. Diagnostics (Basel). 2019 Jul 18;9(3):78. doi: 10.3390/diagnostics9030078. PMID: 31323782

 20180608 Jyun-Hao Chang, Shih-Min Chen, Yi-Chen Shih, Min-Jing Zeng

1. Yamakado S, Cho H, Inada M, Morikawa M, Jiang YH, Saito K, Nakaishi K, Watabe S, Takagi H, Kaneda M, Nakatsuma A, Ninomiya M, Imachi H, Arai T, Yoshimoto T, Murao K, Chang JH, Chen SM, Shih YC, Zeng MJ, Ke LY, Chen CH, Yoshimura T, Miura T, Ito E. Urinary adiponectin as a new diagnostic index for chronic kidney disease due to diabetic nephropathy. BMJ Open Diabetes Res Care. 2019 May 30;7(1):e000661. doi: 10.1136/bmjdrc-2019-000661.

20170610 commencement

Philosophy

Teaching philosophy

• To pursue independent learning
• To develop critical judgment
• To enhance international perspectives
• To cultivate talents & professionals

Female STEM talent

Female STEM talent program

STEM領域女性人才培育方面，我們為脂質代謝體人才培育規劃設計跨領域課程，包括整合基礎學科(醫管資及醫技系)、及設計核心實作課程、規劃國際交流與培養國際視野、參加論文競賽與國內外研討會以提高研究量能。其中最具特色的為醫檢科技海外見習的課程，學生為了有所準備，會提前進入教師研究室學習，並爭取校內暑期研究計畫及校外的大專生國科會計畫，並且積極參與國際交流活動，可謂是推動整項人才培育計畫的關鍵動能。在創新研發規劃方面，我們聚焦質譜醫學、抗體工程、生醫製藥三大面向，藉由籌設之「尖端醫檢科技國際聯合實驗室」，鏈結「南臺灣國際產學聯盟」，多方尋求與企業合作之可能性。

病理技術企業見習：2022.8.1~2022.8.31, 2023.2.1~2022.2.28 學員至立众生技學習病理切片技術。

高中微課程/生物營：2023.3.23~2023.6.15道明中學：生物醫學大解碼 (共12週，每週2小時13:30~15:30)

大學學群講座：2022.12.14高雄市市立新興高中

大學學群講座：2022.11.18嘉義縣國立新港藝術高中

大學入門講座：2022.10.15系友回娘家系列活動

傑出女性科學家講座：2022.11.18 Dr. Fu Chun-Yu (Institute for Biochemistry, University of Cologne)

傑出女性科學家講座：2023.4.14 Assoc. Prof. Wen-Hui Lien (de Duve Institute, University of Louvain, Belgium)

STEM領域人才培育成果發表暨論文競賽：本計畫於2023.6.2~2023.6.4舉辦「2023 International Symposium on Biosciences for Human Health」國際研討會，會議邀請國內外專家學術演講，邀請日本早稻田大學伊藤悅朗教授、德國科隆大學Guenter Schwarz教授來台，建立與醫技系專任教師、校內外合聘教師、長期合作之校友與產業人士之連結，希望能拓展未來的研究合作，也希望能促進雙方認識，促成雙聯學制。本會議同時舉辦學生論文競賽，經由初審委員針對英文摘要給分評選，共12位學生經初選進入決賽，其中包括7位女性學生Shivangi Singh、劉思慧、程佳琪、陳宇彤、陳沛漩、薛智方、蘇玟秀。

2023年期末總結式訓練課程–脂質人才培育：有鑑於臺灣成功爭取到2024國際脂質年會 (ICBL 2024) 的主辦權，有助於脂質研究領域吸引更多國際矚目、資源、和交流，因此台灣大學李心予及沈湯龍教授先行舉辦臺灣脂質研究高峰會 (Taiwan Lipid Research Summit; TLRS)。2023.7.2~2023.7.4兩位教授舉辦第二屆台灣脂質研究高峰會 (2nd TLRS)，會議中邀集脂質領域的專家學者，透過講演和交流會的模式，分享國內外最新研究成果，來進一步連結產官學研社群，並由首屆高峰會已建立的 ICBL 籌備委員會，帶領大家共同討論與籌劃ICBL 2024於台灣主辦事宜，使脂質領域的學術研究更趨應用與國際化。

2023年期末總結式訓練課程–Cambridge Innovation Center 企業見習：2023.7.7~2023.7.21高醫醫技系柯良胤教授及義守大學醫技系詹華蓁助理教授帶兩位學生至美國波士頓Cambridge Innovation Center 企業見習，並參訪附近新創聚落LabCentral及Harvard Innovation Labs。回程時，師生至Rutgers University, New Jersey拜訪Dr. Wei Dai，參訪Rutgers CryoEM & Nanoimaging Facility, Institute for Quantitative Biomedicine (IQB), Center for Advanced Proteomics等機構。

2023年期末總結式訓練課程–醫技系蔡婉琪副教授執行教育部STEM女性人才培育計畫-帶隊學生參加亞洲生技論壇。